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<p><b>New page</b></p><div>'''NPAS2''' ('''Neuronal PAS Domain Protein 2''') is a [[protein]] that in humans is encoded by the '''NPAS2''' [[gene]]. It is a member of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) family of [[transcription factor]]s. <br />
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== Function ==<br />
The NPAS2 protein is a transcription factor that is highly expressed in the [[brain]], particularly in the [[forebrain]], a region involved in higher cognitive functions. It is thought to play a key role in maintaining the [[circadian rhythm]], which regulates the body's internal clock. <br />
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NPAS2 forms a heterodimer with BMAL1, another circadian protein, and this complex binds to E-box elements in the promoter region of target genes to activate their transcription. The NPAS2-BMAL1 complex is negatively regulated by the proteins PER and CRY.<br />
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== Clinical significance ==<br />
Mutations in the NPAS2 gene have been associated with [[seasonal affective disorder]], [[bipolar disorder]], and [[major depressive disorder]]. In addition, some studies have suggested a link between NPAS2 and susceptibility to [[cancer]], particularly [[breast cancer]].<br />
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== See also ==<br />
* [[Circadian rhythm]]<br />
* [[Transcription factor]]<br />
* [[BMAL1]]<br />
* [[PER protein]]<br />
* [[CRY protein]]<br />
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== References ==<br />
<references /><br />
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[[Category:Transcription factors]]<br />
[[Category:Circadian rhythm]]<br />
[[Category:Genes]]<br />
[[Category:Proteins]]<br />
[[Category:Neuroscience]]<br />
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