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<p><b>New page</b></p><div>'''NLRP12''' is a protein that in humans is encoded by the NLRP12 gene. It is a member of the NOD-like receptor family and plays a crucial role in the regulation of inflammatory pathways and innate immune response. <br />
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== Function ==<br />
The protein encoded by the NLRP12 gene is a member of the [[NOD-like receptor]] family. These proteins are characterized by a nucleotide-binding domain (NBD) and leucine-rich repeat (LRR) region. This protein has been shown to specifically inhibit the activation of [[NF-kappaB]], and consequently, play a role in the regulation of inflammation and the innate immune response. <br />
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== Clinical significance ==<br />
Mutations in the NLRP12 gene have been associated with hereditary periodic fever syndromes, specifically [[Familial Cold Autoinflammatory Syndrome 2]] (FCAS2). This condition is characterized by episodes of fever, skin rash and joint pain. <br />
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== See also ==<br />
* [[NOD-like receptor]]<br />
* [[Familial Cold Autoinflammatory Syndrome 2]]<br />
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== References ==<br />
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== External links ==<br />
* [https://www.ncbi.nlm.nih.gov/gene/91662 NCBI Gene]<br />
* [https://www.uniprot.org/uniprot/Q86VI4 UniProt]<br />
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[[Category:Proteins]]<br />
[[Category:Genes]]<br />
[[Category:Immune system]]<br />
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