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'''NFE2L3''' (Nuclear factor erythroid 2-related factor 3) is a [[protein]] that in humans is encoded by the ''NFE2L3'' [[gene]]. It is a member of the [[Cap 'n' Collar]] type of basic region leucine zipper factor family (CNC-bZip) of [[transcription factors]].

== Function ==
NFE2L3 is a transcription factor that is involved in the regulation of [[cellular]] responses to [[oxidative stress]]. It is believed to play a role in the protection of cells from oxidative damage by regulating the expression of genes involved in [[antioxidant]] defense.

== Structure ==
The NFE2L3 protein is composed of several domains, including a basic region that is involved in DNA binding, a leucine zipper region that is involved in protein-protein interactions, and a transactivation domain that is involved in the activation of transcription.

== Clinical significance ==
Alterations in the expression of NFE2L3 have been associated with several types of [[cancer]], including [[lung cancer]], [[breast cancer]], and [[colorectal cancer]]. It is thought that these alterations may contribute to the development and progression of these cancers by affecting the regulation of cellular responses to oxidative stress.

== Research ==
Research is ongoing to further understand the role of NFE2L3 in cellular responses to oxidative stress and its potential as a target for the development of new treatments for cancer.

== See also ==
* [[NFE2L2]]
* [[NFE2L1]]
* [[Oxidative stress]]
* [[Transcription factor]]

== References ==
<references />

[[Category:Transcription factors]]
[[Category:Human proteins]]
[[Category:Genes]]
[[Category:Oncology]]
[[Category:Cell biology]]

{{medicine-stub}}

NFE2L3 - Revision history

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