https://wikimd.org/index.php?action=history&feed=atom&title=NFE2L1NFE2L1 - Revision history2026-04-25T16:24:46ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=NFE2L1&diff=5380115&oldid=prevPrab: CSV import2024-03-10T07:12:48Z<p>CSV import</p>
<p><b>New page</b></p><div>'''NFE2L1''' (Nuclear Factor, Erythroid 2 Like 1), also known as '''NRF1''' (Nuclear Respiratory Factor 1), is a protein that in humans is encoded by the NFE2L1 gene. It is a transcription factor that plays a crucial role in the regulation of genes involved in antioxidant response and cellular stress response.<br />
<br />
== Function ==<br />
NFE2L1 is a member of the [[Cap 'n' Collar]] (CNC) family of transcription factors, which are characterized by a highly conserved basic region and leucine zipper (bZIP) domain. The protein binds to the antioxidant response element (ARE) and activates transcription of target genes. The [[antioxidant]] response element is found in the promoter region of genes involved in detoxification and protection against oxidative stress.<br />
<br />
== Clinical Significance ==<br />
Alterations in the expression of NFE2L1 have been associated with several diseases, including [[cancer]], [[neurodegenerative diseases]], and [[cardiovascular diseases]]. In cancer, NFE2L1 has been found to be overexpressed in certain types of tumors, suggesting a potential role in tumorigenesis. In neurodegenerative diseases, NFE2L1 has been implicated in the regulation of neuronal survival and the response to oxidative stress.<br />
<br />
== Research ==<br />
Research into the role of NFE2L1 in disease is ongoing, with a particular focus on its potential as a therapeutic target. Studies have suggested that modulation of NFE2L1 activity could have beneficial effects in conditions characterized by oxidative stress, such as neurodegenerative diseases and cancer.<br />
<br />
== See Also ==<br />
* [[NFE2L2]]<br />
* [[NFE2L3]]<br />
* [[Antioxidant response element]]<br />
* [[Transcription factor]]<br />
<br />
[[Category:Transcription factors]]<br />
[[Category:Human proteins]]<br />
[[Category:Genes]]<br />
<br />
{{medicine-stub}}<br />
{{biochemistry-stub}}</div>Prab