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<p><b>New page</b></p><div>'''NFASC''' or '''Neurofascin''' is a protein that in humans is encoded by the NFASC gene. Neurofascin is a member of the L1 family of cell adhesion molecules (CAMs) and plays a crucial role in the nervous system, particularly in the formation and maintenance of nodes of Ranvier and axonal growth.<br />
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== Function ==<br />
Neurofascin is an [[L1 family]] cell adhesion molecule involved in the formation of [[Nodes of Ranvier]], the small gaps in the insulating [[myelin sheath]] where [[action potentials]] are generated in neurons. It is also involved in the growth of [[axon]]s, the long threadlike part of a nerve cell along which impulses are conducted from the cell body to other cells.<br />
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== Clinical significance ==<br />
Mutations in the NFASC gene have been associated with [[neurological disorders]], including [[autism]] and [[schizophrenia]]. In addition, autoantibodies against neurofascin have been found in patients with [[autoimmune diseases]], such as [[multiple sclerosis]] and [[neuromyelitis optica]].<br />
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== See also ==<br />
* [[L1 family]]<br />
* [[Nodes of Ranvier]]<br />
* [[Myelin sheath]]<br />
* [[Action potential]]<br />
* [[Axon]]<br />
* [[Neurological disorders]]<br />
* [[Autism]]<br />
* [[Schizophrenia]]<br />
* [[Autoimmune diseases]]<br />
* [[Multiple sclerosis]]<br />
* [[Neuromyelitis optica]]<br />
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== References ==<br />
<references /><br />
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== External links ==<br />
* [https://www.ncbi.nlm.nih.gov/gene/23114 NFASC] at the [[National Center for Biotechnology Information]]<br />
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[[Category:Proteins]]<br />
[[Category:Cell adhesion molecules]]<br />
[[Category:Neurology]]<br />
[[Category:Genes]]<br />
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