Prab: CSV import

2024-03-10T06:56:37Z

CSV import

New page

'''NEFM''' (Neurofilament Medium) is a type of [[neurofilament]] protein that is crucial for the structural support and function of [[neurons]]. It is one of the three main types of neurofilament proteins, along with [[NEFL|NEFL (Neurofilament Light)]] and [[NEFH|NEFH (Neurofilament Heavy)]].

== Structure ==
NEFM is a medium-sized neurofilament protein, typically around 95-105 kDa in size. It is composed of a central [[alpha-helical]] rod domain flanked by non-helical head and tail domains. The rod domain is responsible for the protein's ability to form filaments, while the head and tail domains are involved in interactions with other cellular components.

== Function ==
NEFM plays a critical role in maintaining the structural integrity of neurons. It helps to form a supportive network within the [[axon]], providing a scaffold for the transport of cellular components and contributing to the overall shape and size of the neuron. In addition, NEFM is involved in regulating the speed of [[axon transport]], which is essential for the proper functioning of the nervous system.

== Clinical significance ==
Alterations in NEFM have been associated with a number of neurological disorders. For example, mutations in the NEFM gene have been linked to [[Charcot-Marie-Tooth disease]], a hereditary neuropathy characterized by muscle weakness and sensory loss. Additionally, abnormal accumulation of NEFM has been observed in several neurodegenerative diseases, including [[Alzheimer's disease]] and [[Amyotrophic lateral sclerosis|ALS (Amyotrophic Lateral Sclerosis)]].

== See also ==
* [[Neurofilament]]
* [[NEFL]]
* [[NEFH]]

== References ==
<references />

{{medicine-stub}}

[[Category:Proteins]]
[[Category:Neurology]]
[[Category:Neuroscience]]
[[Category:Medical terminology]]

NEFM - Revision history

Prab: CSV import