https://wikimd.org/index.php?action=history&feed=atom&title=NCOA5 2026-04-25T22:35:07Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=NCOA5&diff=5379759&oldid=prev 2024-03-10T06:45:19Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;NCOA5&#039;&#039;&#039; (Nuclear Receptor Coactivator 5) is a [[protein]] that in humans is encoded by the NCOA5 [[gene]]. This protein is part of the [[nuclear receptor]] coactivator family and plays a critical role in [[cellular]] processes such as [[cell cycle]] regulation and [[apoptosis]].<br /> <br /> == Function ==<br /> <br /> NCOA5 is a coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits [[p300/CBP-associated factor]] and [[cyclic AMP]] response element-binding protein (CREB) to the transcriptional complex. It plays a role in the regulation of the cell cycle and apoptosis.<br /> <br /> == Clinical significance ==<br /> <br /> Alterations in the NCOA5 gene have been associated with an increased risk of [[type 2 diabetes]] and [[breast cancer]]. Studies have shown that NCOA5 is a potential tumor suppressor gene and its downregulation may contribute to the progression of breast cancer.<br /> <br /> == See also ==<br /> <br /> * [[Nuclear receptor]]<br /> * [[Coactivator (genetics)]]<br /> * [[Cell cycle]]<br /> * [[Apoptosis]]<br /> * [[Type 2 diabetes]]<br /> * [[Breast cancer]]<br /> <br /> == References ==<br /> <br /> &lt;references /&gt;<br /> <br /> [[Category:Genes]]<br /> [[Category:Proteins]]<br /> [[Category:Cell biology]]<br /> [[Category:Oncology]]<br /> [[Category:Endocrinology]]<br /> [[Category:Diabetes]]<br /> [[Category:Breast cancer]]<br /> <br /> {{Genes on human chromosome 20}}<br /> {{Nuclear receptor coactivators}}<br /> {{medicine-stub}}</div>

Prab