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'''N-Myc''' is a [[protein]] that in humans is encoded by the '''MYCN''' [[gene]]. It is a member of the [[MYC]] family of [[transcription factors]] and plays a crucial role in [[cell growth]], [[cell differentiation]], and [[apoptosis]].

== Function ==
N-Myc is a basic helix-loop-helix (bHLH) transcription factor that binds to the [[E-box]] DNA sequence and regulates the expression of a wide array of genes involved in cell growth and differentiation. It is also involved in the regulation of the cell cycle and apoptosis, acting as a key player in the development and progression of several types of [[cancer]].

== Clinical significance ==
Alterations in the MYCN gene, particularly amplification, are associated with a variety of cancers, most notably [[neuroblastoma]]. High levels of N-Myc are often found in neuroblastoma cells, and this is associated with a poor prognosis. In addition, N-Myc has been implicated in the development of other types of cancer, including [[lung cancer]], [[breast cancer]], and [[glioblastoma]].

== Research ==
Research into N-Myc and its role in cancer has led to the development of several potential therapeutic strategies. These include the use of small molecule inhibitors that target N-Myc, as well as gene therapy approaches that aim to reduce the levels of N-Myc in cancer cells.

== See also ==
* [[MYC (gene)]]
* [[Neuroblastoma]]
* [[Transcription factor]]
* [[Apoptosis]]

== References ==
<references />

[[Category:Genes]]
[[Category:Proteins]]
[[Category:Oncogenes]]
[[Category:Transcription factors]]
[[Category:Apoptosis]]
[[Category:Cell cycle]]
[[Category:Cancer]]

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N-Myc - Revision history

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