https://wikimd.org/index.php?action=history&feed=atom&title=N-Acetylserotonin
N-Acetylserotonin - Revision history
2026-04-29T14:56:13Z
Revision history for this page on the wiki
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https://wikimd.org/index.php?title=N-Acetylserotonin&diff=6495716&oldid=prev
Prab at 00:46, 17 March 2025
2025-03-17T00:46:14Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 00:46, 17 March 2025</td>
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<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== N-Acetylserotonin ==</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>== N-Acetylserotonin ==</div></td></tr>
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Prab
https://wikimd.org/index.php?title=N-Acetylserotonin&diff=6336589&oldid=prev
Prab: CSV import
2025-02-20T01:49:18Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:49, 20 February 2025</td>
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Prab
https://wikimd.org/index.php?title=N-Acetylserotonin&diff=6263314&oldid=prev
Prab: CSV import
2025-02-10T23:15:45Z
<p>CSV import</p>
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 23:15, 10 February 2025</td>
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Prab
https://wikimd.org/index.php?title=N-Acetylserotonin&diff=5206276&oldid=prev
Prab: CSV import
2024-02-22T03:58:33Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''N-Acetylserotonin''' (NAS), also known as '''normelatonin''', is a naturally occurring chemical in the human body that is a precursor to the hormone [[melatonin]]. It is synthesized from the amino acid [[tryptophan]] via the enzyme [[tryptophan hydroxylase]] and the coenzyme [[5-hydroxytryptophan]] (5-HTP). NAS has been found to have antidepressant and neuroprotective effects.<br />
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== Function ==<br />
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N-Acetylserotonin is primarily involved in the synthesis of [[melatonin]], a hormone that regulates sleep-wake cycles. It is converted to melatonin in the pineal gland, a small endocrine gland in the brain, by the enzyme [[hydroxyindole O-methyltransferase]] (HIOMT).<br />
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In addition to its role in melatonin synthesis, NAS also has other functions in the body. It has been found to have antidepressant effects, possibly due to its ability to increase the production of [[brain-derived neurotrophic factor]] (BDNF), a protein that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses.<br />
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NAS also has neuroprotective effects. It has been shown to protect neurons from damage caused by oxidative stress and inflammation, and it may also have potential therapeutic effects in neurodegenerative diseases such as [[Alzheimer's disease]] and [[Parkinson's disease]].<br />
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== Clinical significance ==<br />
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Abnormal levels of N-Acetylserotonin have been associated with several medical conditions. Low levels of NAS have been found in individuals with [[depression]], [[insomnia]], and certain neurodegenerative diseases. On the other hand, high levels of NAS may be associated with [[bipolar disorder]] and [[schizophrenia]].<br />
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Research is ongoing to further understand the role of NAS in these conditions and to explore potential therapeutic uses of NAS or its derivatives in their treatment.<br />
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== See also ==<br />
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* [[Melatonin]]<br />
* [[Tryptophan]]<br />
* [[5-Hydroxytryptophan]]<br />
* [[Brain-derived neurotrophic factor]]<br />
* [[Alzheimer's disease]]<br />
* [[Parkinson's disease]]<br />
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[[Category:Neurotransmitters]]<br />
[[Category:Hormones]]<br />
[[Category:Neurology]]<br />
[[Category:Psychiatry]]<br />
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{{stub}}</div>
Prab