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Mutacin 1140 - Revision history
2026-04-26T20:48:50Z
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<p><b>New page</b></p><div>'''Mutacin 1140''' is a [[lantibiotic]] produced by the bacterium ''[[Streptococcus mutans]]''. It is a potent [[antibiotic]] that has been shown to be effective against a wide range of [[Gram-positive bacteria]], including [[methicillin-resistant Staphylococcus aureus]] (MRSA) and [[vancomycin-resistant Enterococci]] (VRE).<br />
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==Structure and Mechanism of Action==<br />
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Mutacin 1140 is a [[peptide]] composed of 22 [[amino acids]]. It is characterized by the presence of unusual amino acids, such as [[dehydroalanine]] and [[lanthionine]], which are responsible for its unique structure and potent antibiotic activity. <br />
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The mechanism of action of Mutacin 1140 involves binding to the [[lipid II]] molecule, a crucial component of the bacterial cell wall synthesis. This binding inhibits the transglycosylation step in cell wall biosynthesis, leading to cell death.<br />
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==Clinical Applications==<br />
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Due to its potent antibiotic activity, Mutacin 1140 has potential applications in the treatment of infections caused by drug-resistant bacteria. Studies have shown that it is effective against MRSA and VRE, two of the most challenging drug-resistant bacteria in clinical settings. <br />
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Moreover, Mutacin 1140 has a low propensity for inducing resistance, making it a promising candidate for the development of new antibiotics. However, further studies are needed to assess its safety and efficacy in humans.<br />
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==See Also==<br />
* [[Lantibiotic]]<br />
* [[Streptococcus mutans]]<br />
* [[Antibiotic resistance]]<br />
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==References==<br />
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[[Category:Antibiotics]]<br />
[[Category:Peptides]]<br />
[[Category:Bacterial proteins]]<br />
{{pharmacology-stub}}</div>
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