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			== Multiple system atrophy ==
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			File:MSA_aSynuclein.jpg
			File:Gray707.png
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{{Infobox medical condition (new)
| name = Multiple system atrophy
| synonyms =
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| caption = Alpha synuclein immunohistochemistry <br>of the brain showing many glial inclusions
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Multiple System Atrophy (MSA) is a rare, progressive neurodegenerative disorder characterized by a combination of symptoms affecting movement, balance, and the autonomic nervous system. Although its etiology remains unclear, a significant hallmark of MSA is the presence of a misfolded form of the alpha-synuclein protein within neurons.

== Clinical Presentation ==

Patients with MSA often present with a combination of parkinsonian symptoms, such as tremors, bradykinesia (slow movement), rigidity, and postural instability, as well as cerebellar symptoms including [[ataxia]] (impaired coordination of movement). Unlike [[Parkinson's Disease]], however, these symptoms are usually poorly responsive to dopaminergic therapy, which can aid in differential diagnosis.

One of the defining characteristics of MSA is [[autonomic dysfunction]], which can manifest as:

[[Orthostatic hypotension]] (a decrease in blood pressure upon standing)
Impotence
Altered sweating patterns
[[Xerostomia]] (dry mouth)
Urinary retention and incontinence
Voice changes due to vocal cord palsy can also be an early sign of the disorder.

== Pathophysiology ==

Neurodegeneration in MSA affects multiple parts of the brain, including the [[basal ganglia]], [[inferior olivary nucleus]], and [[cerebellum]]. The precise cause of this neuronal loss is not well understood, but it is associated with the presence of abnormal, misfolded alpha-synuclein protein within neuronal cells, leading to cell damage and death.

== Epidemiology ==

MSA typically appears in individuals between the ages of 50-60, with a slightly higher prevalence in men, accounting for approximately 55% of cases.

== Differential Diagnosis ==

While MSA shares some symptoms with Parkinson's Disease, the lack of response to dopaminergic medications, among other differences, helps distinguish the two conditions. MSA should also not be confused with multisystem proteinopathy, a more common muscle wasting syndrome, or with multiple organ dysfunction syndrome/multiple organ system failure, which are severe complications often associated with septic shock or other severe illnesses.

== References ==
<references />
== See Also ==
* [[Parkinson's Disease]]
* [[Ataxia]]
* [[Neurodegenerative disorders]]
* [[Autonomic nervous system]]
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{{Autonomic diseases}}
{{CNS diseases of the nervous system}}
{{DEFAULTSORT:Multiple System Atrophy}}
[[Category:Extrapyramidal and movement disorders]]
[[Category:Rare diseases]]
[[Category:Neurodegenerative disorders]]
[[Category:Peripheral nervous system disorders]]
[[Category:Syndromes affecting the nervous system]]
[[Category:Deaths from multiple system atrophy]]

Multiple system atrophy - Revision history

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