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 '''Multidrug-resistant tuberculosis''' ('''MDR-TB''') is a form of [[tuberculosis]] (TB) infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB medications (drugs), [[isoniazid]] and [[rifampin]]. Some forms of TB are also resistant to second-line medications, and are called extensively drug-resistant TB ([[XDR-TB]]).
 == Causes ==
 MDR-TB is caused by [[Mycobacterium tuberculosis]] that is resistant to at least isoniazid and rifampin, the two most potent TB drugs. Such drug resistance is caused by two key mechanisms: spontaneous mutation and inadequate treatment.
 == Diagnosis ==
 Diagnosis of MDR-TB involves laboratory testing to determine the drugs to which the bacteria are susceptible. This often involves the use of [[culture]] and [[sensitivity testing]], as well as molecular techniques such as [[polymerase chain reaction]] (PCR).
 == Treatment ==
 Treatment of MDR-TB involves the use of second-line drugs, usually four or more anti-TB drugs for a prolonged period of time. The treatment can be expensive, has many side effects, and can be fatal.
 == Epidemiology ==
 MDR-TB is a serious public health problem that threatens progress made in TB care and control worldwide. It is present in virtually all countries surveyed.
 == Prevention ==
 Prevention of MDR-TB involves prompt detection of drug-resistant TB and proper treatment with second-line drugs.
 == See also ==
 * [[Tuberculosis treatment]]
 * [[Extensively drug-resistant tuberculosis]]
 * [[Tuberculosis diagnosis]]
 [[Category:Tuberculosis]]
 [[Category:Drug resistance]]
 [[Category:Infectious diseases]]
 {{Infectious-disease-stub}}

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← Older revision		Revision as of 01:48, 18 February 2025
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	[[Category:Infectious diseases]]		[[Category:Infectious diseases]]
	{{Infectious-disease-stub}}		{{Infectious-disease-stub}}
			==Multidrug-resistant tuberculosis==
			<gallery>
			File:Mycobacterium_tuberculosis_Ziehl-Neelsen_stain_02.jpg\|Mycobacterium tuberculosis Ziehl-Neelsen stain
			File:Pneumothorax_apparatus,_London,_England,_1901-1930_Wellcome_L0058223.jpg\|Pneumothorax apparatus, London, England, 1901-1930
			</gallery>

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New page

'''Multidrug-resistant tuberculosis''' ('''MDR-TB''') is a form of [[tuberculosis]] (TB) infection caused by bacteria that are resistant to treatment with at least two of the most powerful first-line anti-TB medications (drugs), [[isoniazid]] and [[rifampin]]. Some forms of TB are also resistant to second-line medications, and are called extensively drug-resistant TB ([[XDR-TB]]).

== Causes ==

MDR-TB is caused by [[Mycobacterium tuberculosis]] that is resistant to at least isoniazid and rifampin, the two most potent TB drugs. Such drug resistance is caused by two key mechanisms: spontaneous mutation and inadequate treatment.

== Diagnosis ==

Diagnosis of MDR-TB involves laboratory testing to determine the drugs to which the bacteria are susceptible. This often involves the use of [[culture]] and [[sensitivity testing]], as well as molecular techniques such as [[polymerase chain reaction]] (PCR).

== Treatment ==

Treatment of MDR-TB involves the use of second-line drugs, usually four or more anti-TB drugs for a prolonged period of time. The treatment can be expensive, has many side effects, and can be fatal.

== Epidemiology ==

MDR-TB is a serious public health problem that threatens progress made in TB care and control worldwide. It is present in virtually all countries surveyed.

== Prevention ==

Prevention of MDR-TB involves prompt detection of drug-resistant TB and proper treatment with second-line drugs.

== See also ==
* [[Tuberculosis treatment]]
* [[Extensively drug-resistant tuberculosis]]
* [[Tuberculosis diagnosis]]

[[Category:Tuberculosis]]
[[Category:Drug resistance]]
[[Category:Infectious diseases]]
{{Infectious-disease-stub}}

Multidrug-resistant tuberculosis - Revision history

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