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<p><b>New page</b></p><div>[[File:Moracizine.png|thumb|{{PAGENAME}}]]<br>'''Moracizine''' is a [[Class I antiarrhythmic agent]] that was developed for the treatment of [[arrhythmia]]. It is a phenothiazine derivative and is classified as a Class IC antiarrhythmic drug according to the [[Vaughan Williams classification]] system. <br />
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==Pharmacology==<br />
[[Moracizine]] works by blocking the fast inward sodium current, thereby slowing the rate of rise of the action potential, Phase 0. It has a high affinity for the inactivated state of the sodium channel, and has little effect on the resting state. This results in a decrease in the excitability and conduction velocity of the heart tissue, which can help to restore normal rhythm.<br />
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==Clinical Use==<br />
[[Moracizine]] was primarily used for the treatment of ventricular tachycardia and symptomatic ventricular premature beats. However, it was withdrawn from the market due to concerns about its safety and efficacy. <br />
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==Side Effects==<br />
The most common side effects of [[Moracizine]] include dizziness, blurred vision, and gastrointestinal disturbances. More serious side effects can include [[cardiotoxicity]], which can lead to life-threatening arrhythmias.<br />
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==History==<br />
[[Moracizine]] was first synthesized in the 1970s and was marketed under the brand name [[Ethmozine]]. However, it was withdrawn from the market in the early 2000s due to concerns about its safety and efficacy.<br />
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==See Also==<br />
* [[Antiarrhythmic agent]]<br />
* [[Vaughan Williams classification]]<br />
* [[Cardiotoxicity]]<br />
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{{Antiarrhythmic agents}}<br />
{{Phenothiazines}}<br />
[[Category:Antiarrhythmic agents]]<br />
[[Category:Phenothiazines]]<br />
[[Category:Withdrawn drugs]]<br />
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