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Monoamine oxidase B - Revision history
2026-04-29T04:00:53Z
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<p><b>New page</b></p><div>'''Monoamine oxidase B''' ('''MAO-B''') is an [[enzyme]] that is part of the [[monoamine oxidase]] family. It is encoded in humans by the MAOB gene and is involved in the breakdown of [[neurotransmitter]]s in the brain, particularly [[dopamine]], [[norepinephrine]], and [[serotonin]]. <br />
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== Function ==<br />
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MAO-B is found in the [[mitochondria]] of most cell types in the body. It is especially abundant in the [[liver]], [[platelets]], and [[neurons]] of the [[central nervous system]]. The enzyme's primary function is to catalyze the oxidation of monoamines, a type of neurotransmitter. This process is crucial for maintaining proper brain function and regulating mood.<br />
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== Clinical significance ==<br />
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Abnormal levels of MAO-B have been linked to several neurological disorders. High levels of the enzyme have been found in patients with [[Parkinson's disease]], suggesting that MAO-B may play a role in the disease's progression. In contrast, low levels of MAO-B have been associated with [[depression]] and [[anxiety]] disorders.<br />
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== Inhibitors ==<br />
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[[MAO inhibitors]] are a class of drugs that block the action of monoamine oxidases. MAO-B inhibitors specifically target MAO-B and are used to treat symptoms of Parkinson's disease. These drugs work by preventing the breakdown of dopamine, thereby increasing its availability in the brain.<br />
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== See also ==<br />
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* [[Monoamine oxidase A]]<br />
* [[Monoamine oxidase inhibitor]]<br />
* [[Parkinson's disease]]<br />
* [[Depression]]<br />
* [[Anxiety]]<br />
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{{Enzymes}}<br />
{{Neurotransmitters}}<br />
{{Mental health}}<br />
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[[Category:Enzymes]]<br />
[[Category:Neurotransmitters]]<br />
[[Category:Mental health]]<br />
[[Category:Neurology]]<br />
[[Category:Psychiatry]]<br />
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{{medicine-stub}}</div>
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