https://wikimd.org/index.php?action=history&feed=atom&title=Molidustat 2026-04-27T06:31:07Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Molidustat&diff=6334657&oldid=prev 2025-02-20T01:29:42Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:29, 20 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l30">Line 30:</td> <td colspan="2" class="diff-lineno">Line 30:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Molidustat.svg|Molidustat</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=Molidustat&diff=5298703&oldid=prev 2024-02-25T21:34:24Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Molidustat&#039;&#039;&#039; is a drug that is currently under development by [[Bayer]] for the treatment of [[anemia]] associated with [[chronic kidney disease]]. It is an inhibitor of [[prolyl hydroxylase]], which is an enzyme that plays a crucial role in the body&#039;s response to low oxygen levels. By inhibiting this enzyme, molidustat stimulates the production of [[erythropoietin]], a hormone that promotes the formation of red blood cells.<br /> <br /> == Mechanism of Action ==<br /> <br /> Molidustat works by inhibiting the enzyme [[prolyl hydroxylase]]. This enzyme is responsible for the degradation of [[hypoxia-inducible factor]] (HIF), a protein that regulates the body&#039;s response to low oxygen levels. When prolyl hydroxylase is inhibited, HIF is stabilized and can increase the production of erythropoietin, a hormone that stimulates the production of red blood cells.<br /> <br /> == Clinical Trials ==<br /> <br /> Several clinical trials have been conducted to evaluate the safety and efficacy of molidustat. In a phase IIb study, molidustat was found to be as effective as [[darbepoetin alfa]], a commonly used treatment for anemia associated with chronic kidney disease. A phase III trial is currently underway.<br /> <br /> == Potential Benefits ==<br /> <br /> Molidustat has the potential to offer several benefits over current treatments for anemia associated with chronic kidney disease. It can be taken orally, whereas many current treatments require injection. Additionally, because it works by stimulating the body&#039;s natural response to low oxygen levels, it may have fewer side effects than other treatments.<br /> <br /> == See Also ==<br /> <br /> * [[Anemia]]<br /> * [[Chronic kidney disease]]<br /> * [[Erythropoietin]]<br /> * [[Prolyl hydroxylase]]<br /> <br /> == References ==<br /> <br /> &lt;references /&gt;<br /> <br /> [[Category:Drugs]]<br /> [[Category:Anemia]]<br /> [[Category:Chronic kidney disease]]<br /> [[Category:Bayer]]<br /> <br /> {{stub}}</div>

Prab