https://wikimd.org/index.php?action=history&feed=atom&title=Minoxidil 2026-04-25T20:59:22Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Minoxidil&diff=4960261&oldid=prev 2023-04-06T17:45:58Z

<p></p> <p><b>New page</b></p><div>{{intro}}<br /> Minoxidil is an [[antihypertensive]] agent that is used largely for patients with severe and refractory [[hypertension]] not responding to conventional therapies. Minoxidil is also used topically to treat male pattern baldness. <br /> [[File:Minoxidil structure.svg|thumb|Minoxidil structure]]<br /> {{livtox}}<br /> Despite its use for many years, minoxidil has not been convincingly linked to cases of clinically apparent liver injury.<br /> {{moa}}<br /> Minoxidil (min ox&#039; i dil) is one of the first [[antihypertensive]] agents developed for use in humans. Minoxidil is activated in the liver and acts to relax vascular smooth muscle by opening cell surface potassium channels causing an efflux of potassium, hyperpolarization and relaxation of smooth muscle cells. The increased vasodilation caused by minoxidil can result in a reflex increase in cardiac output and sodium retention for which reasons it is not recommended as monotherapy or as a first line agent for [[hypertension]]. <br /> {{fda}}<br /> Minoxidil was approved for use in the United States in 1979 and continues to be used for treatment of severe and refractory [[hypertension]], usually in combination with beta blockers and diuretics. Minoxidil is available in tablets of 2.5 and 10 mg in generic forms and under the brand name Loniten. <br /> {{dose}}<br /> The usual initial dose in adults is 2.5 to 5 mg once daily, with subsequent adjustment based upon tolerance and clinical effect to a typical maintenance dose is 10 to 40 mg daily. <br /> {{se}}<br /> Minoxidil has many side effects including sodium retention, edema, [[headache]], [[nausea]], breast tenderness, gynecomastia, hypertrichosis and rash. The effect on hair growth has led to the use of topical minoxidil to treat male pattern baldness.<br /> {{antihypertensives}}<br /> {{coststubd}}<br /> {{Nonsympatholytic vasodilatory antihypertensives}}<br /> {{Other dermatological preparations}}<br /> {{Ion channel modulators}}<br /> {{Portal bar | Medicine}}<br /> [[Category:Amine oxides]]<br /> [[Category:Aminopyrimidines]]<br /> [[Category:Antihypertensive agents]]<br /> [[Category:Hair loss medications]]<br /> [[Category:1-Piperidinyl compounds]]<br /> [[Category:Potassium channel openers]]<br /> [[Category:Prodrugs]]<br /> [[Category:Vasodilators]]</div>

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