https://wikimd.com/index.php?action=history&feed=atom&title=Microcin 2026-04-04T23:42:02Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Microcin&diff=6348511&oldid=prev 2025-02-27T00:37:59Z

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Prab https://wikimd.com/index.php?title=Microcin&diff=5386109&oldid=prev 2024-03-11T00:22:56Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Microcin&#039;&#039;&#039; is a type of [[bacteriocin]], a proteinaceous or peptidic toxin produced by bacteria to inhibit the growth of similar or closely related bacterial strain(s). Microcins are produced by and active against [[Gram-negative bacteria]]. They are smaller than other bacteriocins, with a molecular weight less than 10 kDa.<br /> <br /> == Classification ==<br /> <br /> Microcins are classified into two classes based on their molecular weight and post-translational modifications. Class I microcins are less than 5 kDa and undergo extensive post-translational modifications, while Class II microcins are 5-10 kDa and undergo limited post-translational modifications.<br /> <br /> == Mechanism of Action ==<br /> <br /> Microcins exert their antibacterial activity by different mechanisms, including DNA gyrase inhibition, pore formation, and RNase activity. For instance, microcin B17 inhibits [[DNA gyrase]], a type II topoisomerase, which is essential for DNA replication and transcription in bacteria.<br /> <br /> == Biosynthesis ==<br /> <br /> The biosynthesis of microcins involves a nonribosomal peptide synthetase system. The genes responsible for the production, secretion, and immunity of microcins are usually organized in an operon.<br /> <br /> == Applications ==<br /> <br /> Due to their potent antibacterial activity, microcins have potential applications in agriculture and medicine, particularly in the treatment of [[antibiotic-resistant]] bacterial infections.<br /> <br /> == See Also ==<br /> * [[Bacteriocin]]<br /> * [[Antibiotic resistance]]<br /> * [[DNA gyrase]]<br /> * [[Nonribosomal peptide]]<br /> <br /> [[Category:Bacteriology]]<br /> [[Category:Microbiology]]<br /> [[Category:Antibiotics]]<br /> [[Category:Protein biosynthesis]]<br /> <br /> {{medicine-stub}}</div>

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