https://wikimd.com/index.php?action=history&feed=atom&title=Metomidate 2026-04-20T01:13:43Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Metomidate&diff=6333644&oldid=prev 2025-02-20T01:20:39Z

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<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Metomidate&#039;&#039;&#039; is a drug used in veterinary medicine for anesthesia. It is an imidazole derivative, and its mechanism of action involves the inhibition of the enzyme 11β-hydroxylase, which is involved in the final step of cortisol synthesis in the adrenal cortex. This results in a decrease in cortisol levels, which can be beneficial in certain medical conditions.<br /> <br /> == Pharmacology ==<br /> <br /> [[Metomidate]] acts as a non-barbiturate hypnotic. It is a potent inhibitor of the enzyme 11β-hydroxylase, which is involved in the final step of cortisol synthesis in the adrenal cortex. This inhibition results in a decrease in cortisol levels. Metomidate also has a weak analgesic effect.<br /> <br /> == Uses ==<br /> <br /> Metomidate is used in veterinary medicine for anesthesia. It is particularly useful in situations where a rapid and smooth induction of anesthesia is required, such as in emergency surgery. It is also used in the induction of anesthesia in animals with compromised cardiovascular function, as it has minimal effects on cardiovascular stability.<br /> <br /> == Side Effects ==<br /> <br /> The most common side effects of metomidate include respiratory depression, hypotension, and bradycardia. These effects are usually transient and resolve with supportive care. Other potential side effects include nausea, vomiting, and allergic reactions.<br /> <br /> == See Also ==<br /> <br /> * [[Anesthesia]]<br /> * [[Veterinary Medicine]]<br /> * [[Cortisol]]<br /> * [[11β-Hydroxylase]]<br /> <br /> == References ==<br /> <br /> &lt;references /&gt;<br /> <br /> [[Category:Drugs]]<br /> [[Category:Veterinary Medicine]]<br /> [[Category:Anesthesia]]<br /> <br /> {{stub}}</div>

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