https://wikimd.org/index.php?action=history&feed=atom&title=Mertansine 2026-04-26T15:03:04Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Mertansine&diff=6336566&oldid=prev 2025-02-20T01:49:03Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:49, 20 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l27">Line 27:</td> <td colspan="2" class="diff-lineno">Line 27:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{pharmacology-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{pharmacology-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== Mertansine ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Mertansine mab structure coloured.svg|Mertansine</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Emtansine mab structure coloured.svg|Emtansine</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> <!-- diff cache key wikimd4:diff:1.41:old-5374943:rev-6336566:php=table --> </table>

Prab https://wikimd.org/index.php?title=Mertansine&diff=5374943&oldid=prev 2024-03-08T18:41:02Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Mertansine&#039;&#039;&#039; is a [[cytotoxic agent]] used in the creation of [[antibody-drug conjugates]] (ADCs). It is also known by its chemical name, DM1, and is derived from [[maytansinoids]], a group of compounds related to [[maytansine]]. <br /> <br /> ==Chemistry==<br /> Mertansine is a [[maytansinoid]], a type of [[ansamycin]] antibiotic. It is a potent [[microtubule]]-disrupting agent, which prevents the formation of the [[mitotic spindle]], thereby inhibiting [[cell division]]. This makes it a useful tool in the treatment of rapidly dividing [[cancer]] cells.<br /> <br /> ==Use in Medicine==<br /> In the field of [[oncology]], mertansine is used as a cytotoxic component of antibody-drug conjugates. These are designed to deliver the cytotoxic agent directly to cancer cells, thereby reducing the impact on healthy cells. One such ADC is [[Trastuzumab emtansine]], which combines mertansine with the monoclonal antibody [[trastuzumab]].<br /> <br /> ==Pharmacology==<br /> Mertansine works by binding to [[tubulin]], a protein that forms the microtubules necessary for cell division. By preventing the formation of these microtubules, mertansine inhibits the process of [[mitosis]], leading to cell death. <br /> <br /> ==Safety and Side Effects==<br /> Like all cytotoxic agents, mertansine can have serious side effects. These can include [[nausea]], [[vomiting]], [[hair loss]], and [[myelosuppression]]. It is therefore important that mertansine is used under the supervision of a healthcare professional.<br /> <br /> ==See Also==<br /> * [[Antibody-drug conjugate]]<br /> * [[Maytansinoid]]<br /> * [[Trastuzumab emtansine]]<br /> <br /> ==References==<br /> &lt;references /&gt;<br /> <br /> [[Category:Chemotherapy agents]]<br /> [[Category:Antibody-drug conjugates]]<br /> [[Category:Cytotoxic drugs]]<br /> [[Category:Pharmacology]]<br /> <br /> {{pharmacology-stub}}</div>

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