https://wikimd.com/index.php?action=history&feed=atom&title=Mericitabine 2026-04-08T20:23:21Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Mericitabine&diff=6334948&oldid=prev 2025-02-20T01:32:24Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:32, 20 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l25">Line 25:</td> <td colspan="2" class="diff-lineno">Line 25:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Roche]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Roche]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Mericitabine structure.png|Mericitabine</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

Prab https://wikimd.com/index.php?title=Mericitabine&diff=5328880&oldid=prev 2024-02-29T02:39:39Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Mericitabine&#039;&#039;&#039; is an experimental [[antiviral drug]] developed for the treatment of [[hepatitis C]]. It is a [[nucleoside analogue]], which means it mimics the structure of nucleosides, the building blocks of DNA and RNA. Mericitabine is specifically a [[cytidine]] analogue, and it works by inhibiting the replication of the hepatitis C virus.<br /> <br /> == History ==<br /> <br /> Mericitabine was developed by [[Roche]], a Swiss multinational healthcare company. The drug entered Phase 2 clinical trials in 2008, and Phase 3 trials in 2011. However, in 2013, Roche decided to discontinue the development of Mericitabine due to the emergence of more effective treatments for hepatitis C.<br /> <br /> == Mechanism of Action ==<br /> <br /> Mericitabine works by inhibiting the [[RNA-dependent RNA polymerase]] (RdRp) of the hepatitis C virus. RdRp is an essential enzyme for the replication of the virus. By inhibiting this enzyme, Mericitabine prevents the virus from replicating and spreading in the body.<br /> <br /> == Clinical Trials ==<br /> <br /> In clinical trials, Mericitabine was generally well tolerated and showed promising antiviral activity. However, it was less effective than newer treatments, such as [[sofosbuvir]] and [[ledipasvir]], which led to the discontinuation of its development.<br /> <br /> == See Also ==<br /> <br /> * [[Antiviral drug]]<br /> * [[Hepatitis C]]<br /> * [[Nucleoside analogue]]<br /> * [[Roche]]<br /> <br /> [[Category:Antiviral drugs]]<br /> [[Category:Hepatitis C]]<br /> [[Category:Experimental drugs]]<br /> [[Category:Roche]]<br /> {{medicine-stub}}</div>

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