https://wikimd.com/index.php?action=history&feed=atom&title=Mecasermin 2026-04-22T23:34:48Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Mecasermin&diff=5339240&oldid=prev 2024-03-02T02:03:03Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Mecasermin&#039;&#039;&#039; is a synthetic form of [[insulin-like growth factor 1]] (IGF-1), a hormone that stimulates growth in the body. It is used to treat growth failure in children with severe primary IGF-1 deficiency or with [[growth hormone]] (GH) gene deletion who have developed neutralizing antibodies to growth hormone.<br /> <br /> ==Medical Uses==<br /> Mecasermin is used to treat growth failure in children with severe primary IGF-1 deficiency or with growth hormone gene deletion who have developed neutralizing antibodies to growth hormone. It is not used for growth hormone deficiency, [[malnutrition]], [[hypothyroidism]], or long-term treatment of pediatric patients with growth failure due to genetically confirmed [[Prader-Willi syndrome]].<br /> <br /> ==Pharmacology==<br /> Mecasermin is a recombinant DNA-derived drug that is identical in sequence to naturally occurring human insulin-like growth factor-1. It binds to the [[IGF-1 receptor]] which is present on many cell types in many tissues. This binding promotes cell growth and multiplication, as well as cell survival.<br /> <br /> ==Side Effects==<br /> Common side effects of mecasermin include [[hypoglycemia]], injection site reactions, [[lipohypertrophy]], tonsillar hypertrophy, and [[snoring]]. Serious side effects may include [[hypoglycemia]], [[intracranial hypertension]], and [[allergic reactions]].<br /> <br /> ==History==<br /> Mecasermin was approved for medical use in the United States in 2005. It is marketed under the brand name Increlex by [[Ipsen]].<br /> <br /> ==See Also==<br /> * [[Insulin-like growth factor 1]]<br /> * [[Growth hormone]]<br /> * [[Prader-Willi syndrome]]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Endocrinology]]<br /> [[Category:Pediatrics]]<br /> {{Pharma-stub}}<br /> {{Medicine-stub}}</div>

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