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Maropitant - Revision history
2026-04-21T23:24:24Z
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<p><b>New page</b></p><div>'''Maropitant''' is a [[neurokinin-1 (NK1) receptor antagonist]] that is used in veterinary medicine to prevent [[vomiting]] and [[nausea]] in dogs and cats. It is marketed under the trade name Cerenia by [[Zoetis]] and is available in both injectable and oral forms.<br />
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==Etymology==<br />
The name "Maropitant" is derived from the chemical name of the drug, which is (2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-pyridyl)methyl]piperazine-1-carboxamide.<br />
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==Pharmacology==<br />
Maropitant is a potent, selective, non-peptide antagonist of the [[neurokinin 1 (NK1) receptor]]. The NK1 receptor is a G-protein coupled receptor located in the central and peripheral nervous system. It is primarily involved in the transmission of pain, and its activation leads to the sensation of nausea and the reflex of vomiting. By blocking the NK1 receptor, maropitant prevents the action of its natural ligand, [[substance P]], thus preventing the sensation of nausea and the reflex of vomiting.<br />
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==Uses==<br />
Maropitant is used in dogs and cats to prevent and treat acute vomiting, and to prevent vomiting due to motion sickness. It is also used to prevent vomiting associated with chemotherapy in dogs.<br />
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==Side effects==<br />
The most common side effects of maropitant include [[hypersalivation]], [[diarrhea]], [[anorexia]], and [[lethargy]]. In rare cases, it can cause changes in behavior, such as hyperactivity or aggression.<br />
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==Related terms==<br />
* [[Neurokinin 1 (NK1) receptor]]<br />
* [[Substance P]]<br />
* [[Vomiting]]<br />
* [[Nausea]]<br />
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[[Category:Veterinary drugs]]<br />
[[Category:Antiemetics]]<br />
[[Category:Neurokinin-1 receptor antagonists]]<br />
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