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Margetuximab - Revision history
2026-04-26T21:55:14Z
Revision history for this page on the wiki
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https://wikimd.org/index.php?title=Margetuximab&diff=6525078&oldid=prev
Prab at 12:59, 18 March 2025
2025-03-18T12:59:59Z
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Prab
https://wikimd.org/index.php?title=Margetuximab&diff=6513228&oldid=prev
Prab: CSV import
2025-03-17T18:41:29Z
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Prab
https://wikimd.org/index.php?title=Margetuximab&diff=6272971&oldid=prev
Prab: CSV import
2025-02-11T03:42:36Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 03:42, 11 February 2025</td>
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Prab
https://wikimd.org/index.php?title=Margetuximab&diff=4515380&oldid=prev
Deepika vegiraju at 13:23, 22 August 2022
2022-08-22T13:23:33Z
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<p><b>New page</b></p><div><br />
== '''What Is Margetuximab?''' ==<br />
<br />
* Margetuximab ('''Margenza''') is a [[HER2/neu]] receptor [[antagonist]].<br />
<br />
<youtube><br />
title='''{{PAGENAME}}'''<br />
movie_url=http://www.youtube.com/v/=KnQ3djv6Kxw<br />
embed_source_url=http://www.youtube.com/v/=KnQ3djv6Kxw<br />
&rel=1<br />
wrap = yes<br />
width=750<br />
height=600<br />
</youtube><br />
<br />
<br />
== '''What are the uses of this medicine?''' ==<br />
<br />
*Margetuximab ('''Margenza''') is indicated, in combination with [[chemotherapy]], for the treatment of adult patients with metastatic [[HER2]]-positive [[breast cancer]] who have received two or more prior anti-[[HER2]] regimens, at least one of which was for [[metastatic]] disease.<br />
<br />
<br />
== '''How does this medicine work?''' ==<br />
<br />
<youtube><br />
title='''{{PAGENAME}}'''<br />
movie_url=http://www.youtube.com/v/v=jq5cqBeL73M<br />
embed_source_url=http://www.youtube.com/v/v=jq5cqBeL73M<br />
&rel=1<br />
wrap = yes<br />
width=750<br />
height=600<br />
</youtube><br />
<br />
* Margetuximab-cmkb binds to the extracellular domain of the human epidermal growth factor receptor 2 protein ([[HER2]]). <br />
* '''Upon binding to HER2-expressing tumor cells, margetuximab-cmkb inhibits tumor cell [[proliferation]], reduces shedding of the HER2 extracellular domain and mediates [[antibody-dependent cellular cytotoxicity]] (ADCC)'''.<br />
<br />
<br />
== '''Who Should Not Use this medicine ?''' ==<br />
<br />
* This medicine have no usage limitations<br />
<br />
<br />
== '''Is this medicine FDA approved?''' ==<br />
<br />
* It was approved for use in the United States in 2020.<br />
<br />
<br />
== '''How should this medicine be used?''' ==<br />
<br />
* Administer Margenza as an intravenous infusion at 15 mg/kg over 120 minutes for the initial dose, then over a minimum of 30 minutes every 3 weeks for all subsequent doses. <br />
* On days when both Margenza and [[chemotherapy]] are to be administered, Margenza may be administered immediately after chemotherapy completion. <br />
<br />
<br />
== '''What are the dosage forms and brand names of this medicine?''' ==<br />
<br />
This medicine is available in fallowing doasage form:<br />
'''As injections:''' 250 mg/10 mL (25 mg/mL) in a single-dose vial<br />
<br />
This medicine is available in fallowing brand namesː<br />
*'''Margenza'''<br />
<br />
<br />
=='''What side effects can this medication cause?'''==<br />
<br />
Common possible side effects and laboratory abnormalities of this medicine include:<br />
* fatigue/[[asthenia]]<br />
* nausea<br />
* diarrhea<br />
* vomiting<br />
* constipation<br />
* headache<br />
* [[pyrexia]]<br />
* [[alopecia]]<br />
* abdominal pain<br />
* [[peripheral neuropathy]]<br />
* [[arthralgia]]/[[myalgia]]<br />
* cough<br />
* decreased appetite<br />
* [[dyspnea]]<br />
* infusion-related reactions<br />
* [[palmar-plantar erythrodysesthesia]]* extremity pain<br />
<br />
<br />
==''' What special precautions should I follow?''' ==<br />
<br />
* Margenza may lead to reductions in [[Left ventricular ejection fraction, estimated|left ventricular ejection fraction]] (LVEF). <br />
* Evaluate cardiac function prior to and during treatment.<br />
* Discontinue Margenza treatment for a confirmed clinically significant decrease in left ventricular function. <br />
* Margenza can cause fetal harm when administered to a pregnant woman. <br />
* Advise patients of the risk and need for effective [[contraception]].<br />
* If a significant infusion-associated reaction occurs, slow or interrupt the infusion and administer appropriate medical therapies.<br />
<br />
<br />
== '''What to do in case of emergency/overdose?''' ==<br />
<br />
* {{overdose}}<br />
<br />
<br />
== '''Can this medicine be used in pregnancy?''' ==<br />
<br />
* Exposure to Margenza during pregnancy can cause embryo-fetal harm.<br />
<br />
<br />
=='''Can this medicine be used in children?'''==<br />
<br />
* Safety and effectiveness of Margenza have not been established in pediatric patients.<br />
<br />
<br />
== '''What should I know about storage and disposal of this medication?''' ==<br />
<br />
* Store vials refrigerated at 2°C to 8°C (36°F to 46°F) in original carton to protect from light until time of use.<br />
* Do not freeze. <br />
* Do not shake.<br />
<br />
{{Monoclonals for tumors}}<br />
{{Portal bar | Medicine}}<br />
<br />
[[Category:Monoclonal antibodies for tumors]]<br />
[[Category:Orphan drugs]]<br />
[[Category:Receptor tyrosine kinase inhibitors]]<br />
{{monoclonal-antibody-stub}}<br />
{{coststubd}}</div>
Deepika vegiraju