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<p><b>New page</b></p><div>[[File:Manidipine.png|thumb|{{PAGENAME}}]]<br>'''Manidipine''' is a [[calcium channel blocker]] (dihydropyridine type) that is used clinically as an [[antihypertensive]]. The substance belongs to the class of [[dihydropyridines]] and has [[antihypertensive]] properties. Manidipine is not registered for use in all countries.<br />
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==Pharmacology==<br />
Manidipine is a potent [[vasodilator]] due to its strong affinity for [[L-type calcium channels]] that are present in the smooth muscle cells of the arterial wall. The blockade of these channels inhibits the influx of [[calcium ions]], which prevents the contraction of the smooth muscle cells and leads to their relaxation. This results in a decrease in [[peripheral vascular resistance]], leading to a decrease in blood pressure.<br />
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==Clinical Use==<br />
Manidipine is used for the treatment of [[hypertension]]. It may be used alone or in combination with other antihypertensive drugs. The drug has a long duration of action that allows for once-daily dosing. Manidipine is well tolerated and has a favorable side effect profile.<br />
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==Side Effects==<br />
The most common side effects of manidipine are related to its vasodilatory action and include [[flushing]], [[headache]], [[palpitations]], and [[ankle swelling]]. Other side effects can include [[dizziness]], [[fatigue]], and [[nausea]]. <br />
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==Contraindications==<br />
Manidipine is contraindicated in patients with known hypersensitivity to dihydropyridines. It should be used with caution in patients with severe [[cardiac insufficiency]] or in patients with severe [[hepatic impairment]].<br />
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==Interactions==<br />
Manidipine can interact with other drugs, such as [[beta-blockers]], [[ACE inhibitors]], and [[diuretics]], which can lead to additive antihypertensive effects. It can also interact with [[CYP3A4 inhibitors]], which can increase the plasma concentration of manidipine.<br />
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==See Also==<br />
* [[Calcium channel blocker]]<br />
* [[Antihypertensive]]<br />
* [[Dihydropyridines]]<br />
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[[Category:Calcium channel blockers]]<br />
[[Category:Antihypertensives]]<br />
[[Category:Dihydropyridines]]<br />
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{{hypertension}}<br />
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