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{{DISPLAYTITLE:MAPK3}}

== Overview ==
'''MAPK3''', also known as '''Mitogen-Activated Protein Kinase 3''', is a protein encoded by the '''MAPK3''' gene in humans. It is a member of the [[mitogen-activated protein kinase]] (MAPK) family, which is involved in various cellular processes such as proliferation, differentiation, and development. MAPK3 is also referred to as '''ERK1''' (Extracellular signal-Regulated Kinase 1) and plays a critical role in the MAPK/ERK signaling pathway.

== Structure ==
MAPK3 is a serine/threonine kinase that is activated by phosphorylation. It consists of a protein kinase domain that is responsible for its enzymatic activity. The activation of MAPK3 involves dual phosphorylation on a threonine and a tyrosine residue within the activation loop of the kinase domain.

== Function ==
MAPK3 is primarily involved in the transduction of extracellular signals into intracellular responses. Upon activation by upstream kinases, MAPK3 translocates to the nucleus where it phosphorylates various transcription factors, thereby regulating gene expression. This signaling cascade is crucial for controlling cell cycle progression, apoptosis, and cellular responses to growth factors and stress.

== Pathway ==
The MAPK/ERK pathway is initiated by the binding of growth factors to receptor tyrosine kinases (RTKs) on the cell surface. This leads to the activation of [[Ras]], a small GTPase, which in turn activates [[Raf]], a MAP kinase kinase kinase (MAPKKK). Raf phosphorylates and activates [[MEK1/2]], which are MAP kinase kinases (MAPKKs). MEK1/2 then phosphorylate and activate MAPK3 (ERK1) and its closely related isoform [[MAPK1]] (ERK2).

== Clinical Significance ==
Dysregulation of MAPK3 activity has been implicated in various diseases, including cancer. Overactivation of the MAPK/ERK pathway can lead to uncontrolled cell proliferation and survival, contributing to tumorigenesis. Inhibitors targeting components of this pathway are being developed as potential therapeutic agents for cancer treatment.

== Research ==
Ongoing research is focused on understanding the precise mechanisms by which MAPK3 regulates cellular functions and its role in disease. Studies are also exploring the development of specific inhibitors that can modulate MAPK3 activity for therapeutic purposes.

== Also see ==
* [[Mitogen-activated protein kinase]]
* [[MAPK1]]
* [[Ras-Raf-MEK-ERK pathway]]
* [[Signal transduction]]
* [[Protein kinase]]

{{Protein-stub}}
{{Receptor tyrosine kinases}}

[[Category:Signal transduction]]
[[Category:Protein kinases]]
[[Category:Human proteins]]

MASP2 - Revision history

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