https://wikimd.com/index.php?action=history&feed=atom&title=Lymph_node_stromal_cell 2026-04-05T21:02:28Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Lymph_node_stromal_cell&diff=5834246&oldid=prev 2024-05-28T00:28:10Z

<p>CSV import</p> <p><b>New page</b></p><div>[[File:Anatomy_and_physiology_of_animals_Lymph_node.jpg|Anatomy and physiology of animals Lymph node|thumb]] &#039;&#039;&#039;Lymph node stromal cell&#039;&#039;&#039;<br /> <br /> [[Lymph node stromal cells]] are a diverse group of non-hematopoietic cells that form the structural framework of the [[lymph node]]. These cells play a crucial role in maintaining the architecture of the lymph node and facilitating the interactions between [[immune cells]].<br /> <br /> ==Types of Lymph Node Stromal Cells==<br /> Lymph node stromal cells can be classified into several types, each with distinct functions and characteristics:<br /> <br /> * &#039;&#039;&#039;[[Fibroblastic reticular cells]] (FRCs)&#039;&#039;&#039;: These cells form a network of fibers that provide structural support and guide the movement of [[T cells]] and [[dendritic cells]] within the lymph node.<br /> * &#039;&#039;&#039;[[Follicular dendritic cells]] (FDCs)&#039;&#039;&#039;: FDCs are found in the [[B cell]] follicles and are essential for the formation and maintenance of [[germinal centers]]. They present [[antigens]] to B cells and support their maturation.<br /> * &#039;&#039;&#039;[[Lymphatic endothelial cells]] (LECs)&#039;&#039;&#039;: These cells line the lymphatic vessels within the lymph node and are involved in the transport of lymph and the migration of immune cells.<br /> * &#039;&#039;&#039;[[Blood endothelial cells]] (BECs)&#039;&#039;&#039;: BECs form the blood vessels within the lymph node and are responsible for the exchange of nutrients and waste products.<br /> <br /> ==Functions==<br /> Lymph node stromal cells perform several critical functions:<br /> <br /> * &#039;&#039;&#039;Structural support&#039;&#039;&#039;: They provide the physical framework that maintains the organization of the lymph node.<br /> * &#039;&#039;&#039;Immune cell interaction&#039;&#039;&#039;: They facilitate the interactions between various immune cells, such as T cells, B cells, and dendritic cells, which are essential for the immune response.<br /> * &#039;&#039;&#039;Antigen presentation&#039;&#039;&#039;: Some stromal cells, like FDCs, present antigens to B cells, aiding in their activation and maturation.<br /> * &#039;&#039;&#039;Homeostasis&#039;&#039;&#039;: They help maintain the homeostasis of the lymph node environment by regulating the movement and localization of immune cells.<br /> <br /> ==Clinical Significance==<br /> Lymph node stromal cells are involved in various pathological conditions, including [[autoimmune diseases]], [[chronic inflammation]], and [[cancer]]. Understanding their role in these conditions can provide insights into potential therapeutic targets.<br /> <br /> ==Related Pages==<br /> * [[Lymph node]]<br /> * [[Immune system]]<br /> * [[T cell]]<br /> * [[B cell]]<br /> * [[Dendritic cell]]<br /> * [[Antigen presentation]]<br /> * [[Autoimmune disease]]<br /> * [[Chronic inflammation]]<br /> * [[Cancer]]<br /> <br /> [[Category:Cell biology]]<br /> [[Category:Immunology]]<br /> [[Category:Medicine]]<br /> <br /> {{Cell-biology-stub}}</div>

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