https://wikimd.org/index.php?action=history&feed=atom&title=Luspatercept 2026-04-26T18:39:39Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Luspatercept&diff=6524991&oldid=prev 2025-03-18T12:59:49Z

<p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:59, 18 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l48">Line 48:</td> <td colspan="2" class="diff-lineno">Line 48:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">__NOINDEX__</del></div></td><td colspan="2" class="diff-side-added"></td></tr> </table>

Prab https://wikimd.org/index.php?title=Luspatercept&diff=6512666&oldid=prev 2025-03-17T17:57:08Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:57, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l48">Line 48:</td> <td colspan="2" class="diff-lineno">Line 48:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=Luspatercept&diff=6272194&oldid=prev 2025-02-11T03:28:49Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 03:28, 11 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l47">Line 47:</td> <td colspan="2" class="diff-lineno">Line 47:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=Luspatercept&diff=5440974&oldid=prev 2024-03-22T10:22:40Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Luspatercept&#039;&#039;&#039; is a recombinant fusion protein used primarily in the treatment of anemia associated with [[Beta Thalassemia]] and [[Myelodysplastic Syndromes]] (MDS). It functions by promoting erythropoiesis (red blood cell production) through a novel mechanism of action, distinguishing it from traditional treatments like erythropoiesis-stimulating agents.<br /> <br /> ==Mechanism of Action==<br /> Luspatercept works by binding to select transforming growth factor-beta (TGF-β) superfamily ligands, thereby reducing Smad2 and Smad3 signaling. This action leads to the maturation of late-stage erythroid precursors, effectively increasing hemoglobin levels and reducing the transfusion burden in patients with anemia due to Beta Thalassemia or lower-risk MDS.<br /> <br /> ==Indications==<br /> The primary indications for Luspatercept include:<br /> * Treatment of anemia in adult patients with Beta Thalassemia who require regular red blood cell (RBC) transfusions.<br /> * Treatment of anemia failing an erythropoiesis stimulating agent and requiring 2 or more RBC transfusions over 8 weeks in adult patients with very low to intermediate-risk MDS with ring sideroblasts (MDS-RS) or with Myelodysplastic/Myeloproliferative Neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T).<br /> <br /> ==Administration==<br /> Luspatercept is administered via subcutaneous injection. The dosage and frequency of administration depend on the specific condition being treated, the patient&#039;s body weight, and their response to therapy.<br /> <br /> ==Side Effects==<br /> Common side effects of Luspatercept include:<br /> * Fatigue<br /> * Headache<br /> * Muscle pains<br /> * Dizziness<br /> * Nausea<br /> * Diarrhea<br /> * Cough<br /> * Fever<br /> <br /> Patients are advised to report any side effects to their healthcare provider. Serious adverse reactions can occur and may require immediate medical attention.<br /> <br /> ==Clinical Trials==<br /> Clinical trials have played a crucial role in the development and approval of Luspatercept. The BELIEVE and MEDALIST trials, among others, have demonstrated its efficacy and safety in treating anemia associated with Beta Thalassemia and MDS, respectively.<br /> <br /> ==Approval==<br /> Luspatercept received approval from the [[Food and Drug Administration]] (FDA) in the United States for specific indications related to anemia associated with Beta Thalassemia and MDS. It has also been approved by the European Medicines Agency (EMA) and other regulatory bodies worldwide.<br /> <br /> ==Future Directions==<br /> Research is ongoing to explore the potential of Luspatercept in treating other conditions and to better understand its long-term safety and efficacy profile. Its novel mechanism of action offers a promising avenue for the development of new therapies targeting anemia and other hematologic conditions.<br /> <br /> ==See Also==<br /> * [[Anemia]]<br /> * [[Beta Thalassemia]]<br /> * [[Myelodysplastic Syndromes]]<br /> * [[Erythropoiesis]]<br /> * [[Transforming Growth Factor Beta]]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Hematology]]<br /> [[Category:Biotechnology products]]<br /> [[Category:Recombinant proteins]]<br /> <br /> {{Medicine-stub}}</div>

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