Lurasidone - Revision history

Prab at 09:07, 27 March 2025

2025-03-27T09:07:12Z

← Older revision		Revision as of 09:07, 27 March 2025
Line 1:		Line 1:

	== '''What is Lurasidone?''' ==		== '''What is Lurasidone?''' ==
			[[File:Lurasidone.svg\|Chemical structure of Lurasidone\|thumb]]
			[[File:Lurasidone_ball-and-stick_based_on_xtal_2012.png\|Ball-and-stick model of Lurasidone\|thumb]]
			[[File:ID-14283_skeletal.svg\|Skeletal formula of Lurasidone\|thumb]]
			[[File:ID-11614_and_20219_skeletal.svg\|Skeletal formula of related compounds\|thumb]]
			[[File:Image_of_Latuda_(Lurasidone)_bottles.png\|Image of Latuda (Lurasidone) bottles\|thumb]]
	* Lurasidone ('''Latuda''') is '''an atypical antipsychotic''' used to treat [[schizophrenia]] and [[bipolar disorder]].		* Lurasidone ('''Latuda''') is '''an atypical antipsychotic''' used to treat [[schizophrenia]] and [[bipolar disorder]].

Line 13:		Line 16:
	height=600		height=600
	</youtube>		</youtube>


	== '''What are the uses of this medicine?''' ==		== '''What are the uses of this medicine?''' ==
Line 21:		Line 23:
	* Alone to treat people 10 years of age and older with depressive episodes that happen with [[Bipolar I Disorder]] ([[bipolar depression]]).		* Alone to treat people 10 years of age and older with depressive episodes that happen with [[Bipolar I Disorder]] ([[bipolar depression]]).
	* With the medicine [[lithium]] or [[valproate]] to treat adults with depressive episodes that happen with Bipolar I Disorder (bipolar depression).		* With the medicine [[lithium]] or [[valproate]] to treat adults with depressive episodes that happen with Bipolar I Disorder (bipolar depression).


	== '''How does this medicine work?''' ==		== '''How does this medicine work?''' ==

	~~<youtube>~~
	~~title='''{{PAGENAME}}'''~~
	~~movie_url=http://www.youtube.com/v=nim8yllCGy8~~
	~~embed_source_url=http://www.youtube.com/v=nim8yllCGy8~~
	~~&rel=1~~
	~~wrap = yes~~
	~~width=750~~
	~~height=600~~
	~~</youtube>~~

	* Lurasidone (loo ras' i done) is '''a second generation [[antipsychotic]] agent''' which appears '''to act as a dopamine type 2 (D2) and serotonin (5-HT)-2A receptor antagonist''' in a manner similar to [[risperidone]].		* Lurasidone (loo ras' i done) is '''a second generation [[antipsychotic]] agent''' which appears '''to act as a dopamine type 2 (D2) and serotonin (5-HT)-2A receptor antagonist''' in a manner similar to [[risperidone]].


	== '''Who Should Not Use this medicine ?''' ==		== '''Who Should Not Use this medicine ?''' ==
Line 43:		Line 33:
	* are allergic to lurasidone hydrochloride or any of the ingredients in Latuda.		* are allergic to lurasidone hydrochloride or any of the ingredients in Latuda.
	* are taking certain other medicines called CYP3A4 inhibitors or inducers including [[ketoconazole]], [[clarithromycin]], [[ritonavir]], [[voriconazole]], [[mibefradil]], [[rifampin]], [[avasimibe]], [[St. John's wort]], [[phenytoin]], or [[carbamazepine]].		* are taking certain other medicines called CYP3A4 inhibitors or inducers including [[ketoconazole]], [[clarithromycin]], [[ritonavir]], [[voriconazole]], [[mibefradil]], [[rifampin]], [[avasimibe]], [[St. John's wort]], [[phenytoin]], or [[carbamazepine]].


	== '''What drug interactions can this medicine cause?''' ==		== '''What drug interactions can this medicine cause?''' ==
Line 52:		Line 41:
	* Latuda dose should be increased when used concomitantly with moderate inducers of CYP3A4 (eg:Bosentan, efavirenz, etravirine, modafinil, nafcillin)		* Latuda dose should be increased when used concomitantly with moderate inducers of CYP3A4 (eg:Bosentan, efavirenz, etravirine, modafinil, nafcillin)
	* No dosage adjustment of Latuda is required when administered concomitantly with [[lithium]], [[valproate]], or substrates of P-gp or CYP3A4.		* No dosage adjustment of Latuda is required when administered concomitantly with [[lithium]], [[valproate]], or substrates of P-gp or CYP3A4.


	== '''Is this medicine FDA approved?''' ==		== '''Is this medicine FDA approved?''' ==

	* Several randomized controlled trials have shown that lurasidone improves symptoms of [[schizophrenia]] and it was approved for this indication and for depressive episodes associated with [[bipolar disorder]] in the United States in 2010.		* Several randomized controlled trials have shown that lurasidone improves symptoms of [[schizophrenia]] and it was approved for this indication and for depressive episodes associated with [[bipolar disorder]] in the United States in 2010.


	== '''How should this medicine be used?''' ==		== '''How should this medicine be used?''' ==
Line 99:		Line 86:
	* Take Latuda by mouth, with food (at least 350 calories).		* Take Latuda by mouth, with food (at least 350 calories).
	* If you take too much Latuda, call your healthcare provider or poison control center or go to the nearest hospital emergency room right away.		* If you take too much Latuda, call your healthcare provider or poison control center or go to the nearest hospital emergency room right away.


	== '''What are the dosage forms and brand names of this medicine?''' ==		== '''What are the dosage forms and brand names of this medicine?''' ==
Line 171:		Line 157:
	* Latuda may cause [[orthostatic hypotension]] and [[syncope]], perhaps due to its α1-adrenergic receptor antagonism. Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope.		* Latuda may cause [[orthostatic hypotension]] and [[syncope]], perhaps due to its α1-adrenergic receptor antagonism. Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope.
	* Latuda may cause [[somnolence]], [[postural hypotension]], motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries.		* Latuda may cause [[somnolence]], [[postural hypotension]], motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries.


	== '''What to do in case of emergency/overdose?''' ==		== '''What to do in case of emergency/overdose?''' ==
Line 186:		Line 171:
	* [[Hypotension]] and [[circulatory collapse]] should be treated with appropriate measures.		* [[Hypotension]] and [[circulatory collapse]] should be treated with appropriate measures.
	* [[Gastric lavage]] (after intubation if patient is unconscious) and administration of activated charcoal together with a laxative should be considered.		* [[Gastric lavage]] (after intubation if patient is unconscious) and administration of activated charcoal together with a laxative should be considered.


	== '''Can this medicine be used in pregnancy?''' ==		== '''Can this medicine be used in pregnancy?''' ==
Line 193:		Line 177:
	* There are no studies of Latuda use in pregnant women.		* There are no studies of Latuda use in pregnant women.
	* The limited available data are not sufficient to inform a drug-associated risk of birth defects or miscarriage.		* The limited available data are not sufficient to inform a drug-associated risk of birth defects or miscarriage.


	=='''Can this medicine be used in children?'''==		=='''Can this medicine be used in children?'''==
Line 206:		Line 189:

	* The effectiveness of Latuda in pediatric patients for the treatment of irritability associated with [[autistic]] disorder has not been established.		* The effectiveness of Latuda in pediatric patients for the treatment of irritability associated with [[autistic]] disorder has not been established.


	== '''What are the active and inactive ingredients in this medicine?''' ==		== '''What are the active and inactive ingredients in this medicine?''' ==
Line 212:		Line 194:
	* '''Active ingredient:''' lurasidone hydrochloride		* '''Active ingredient:''' lurasidone hydrochloride
	* '''Inactive ingredients:''' mannitol, pregelatinized starch, croscarmellose sodium, hypromellose, magnesium stearate, Opadry® and carnauba wax. Additionally, the 80 mg tablet contains yellow ferric oxide and FD&C Blue No. 2 Aluminum Lake		* '''Inactive ingredients:''' mannitol, pregelatinized starch, croscarmellose sodium, hypromellose, magnesium stearate, Opadry® and carnauba wax. Additionally, the 80 mg tablet contains yellow ferric oxide and FD&C Blue No. 2 Aluminum Lake


	== '''Who manufactures and distributes this medicine?''' ==		== '''Who manufactures and distributes this medicine?''' ==
Line 218:		Line 199:
	* '''Manufactured for:''' [[Sunovion Pharmaceuticals]] Inc. Marlborough, MA USA		* '''Manufactured for:''' [[Sunovion Pharmaceuticals]] Inc. Marlborough, MA USA
	Latuda is a registered trademark of Sumitomo Dainippon Pharma Co. Ltd.; Sunovion		Latuda is a registered trademark of Sumitomo Dainippon Pharma Co. Ltd.; Sunovion


	== '''What should I know about storage and disposal of this medication?''' ==		== '''What should I know about storage and disposal of this medication?''' ==
Line 238:		Line 218:
	}}		}}
	{{Portal bar \| Medicine}}		{{Portal bar \| Medicine}}

	[[Category:5-HT7 antagonists]]		[[Category:5-HT7 antagonists]]
	[[Category:2010 introductions]]		[[Category:2010 introductions]]
Line 250:		Line 229:
	[[Category:Mood stabilizers]]		[[Category:Mood stabilizers]]
	[[Category:Piperazines]]		[[Category:Piperazines]]
	~~== Lurasidone ==~~
	~~<gallery>~~
	~~File:Lurasidone.svg\|Chemical structure of Lurasidone~~
	~~File:Lurasidone_ball-and-stick_based_on_xtal_2012.png\|Ball-and-stick model of Lurasidone~~
	~~File:ID-14283_skeletal.svg\|Skeletal formula of Lurasidone~~
	~~File:ID-11614_and_20219_skeletal.svg\|Skeletal formula of related compounds~~
	~~File:Image_of_Latuda_(Lurasidone)_bottles.png\|Image of Latuda (Lurasidone) bottles~~
	~~</gallery>~~

Prab: CSV import

2025-02-18T04:38:49Z

CSV import

← Older revision		Revision as of 04:38, 18 February 2025
Line 250:		Line 250:
	[[Category:Mood stabilizers]]		[[Category:Mood stabilizers]]
	[[Category:Piperazines]]		[[Category:Piperazines]]
			== Lurasidone ==
			<gallery>
			File:Lurasidone.svg\|Chemical structure of Lurasidone
			File:Lurasidone_ball-and-stick_based_on_xtal_2012.png\|Ball-and-stick model of Lurasidone
			File:ID-14283_skeletal.svg\|Skeletal formula of Lurasidone
			File:ID-11614_and_20219_skeletal.svg\|Skeletal formula of related compounds
			File:Image_of_Latuda_(Lurasidone)_bottles.png\|Image of Latuda (Lurasidone) bottles
			</gallery>

Prab: Reverted edits by Prab (talk) to last revision by Deepika vegiraju

2024-03-06T04:23:17Z

Reverted edits by Prab (talk) to last revision by Deepika vegiraju

New page

== '''What is Lurasidone?''' ==

* Lurasidone ('''Latuda''') is '''an atypical antipsychotic''' used to treat [[schizophrenia]] and [[bipolar disorder]].

<youtube>
title='''{{PAGENAME}}'''
movie_url=http://www.youtube.com/v/v=aXqF6K0yhjk
embed_source_url=http://www.youtube.com/v/v=aXqF6K0yhjk
&rel=1
wrap = yes
width=750
height=600
</youtube>

== '''What are the uses of this medicine?''' ==

Lurasidone (Latuda) is a prescription medicine used:
* To treat people 13 years of age or older with [[schizophrenia]].
* Alone to treat people 10 years of age and older with depressive episodes that happen with [[Bipolar I Disorder]] ([[bipolar depression]]).
* With the medicine [[lithium]] or [[valproate]] to treat adults with depressive episodes that happen with Bipolar I Disorder (bipolar depression).

== '''How does this medicine work?''' ==

<youtube>
title='''{{PAGENAME}}'''
movie_url=http://www.youtube.com/v=nim8yllCGy8
embed_source_url=http://www.youtube.com/v=nim8yllCGy8
&rel=1
wrap = yes
width=750
height=600
</youtube>

* Lurasidone (loo ras' i done) is '''a second generation [[antipsychotic]] agent''' which appears '''to act as a dopamine type 2 (D2) and serotonin (5-HT)-2A receptor antagonist''' in a manner similar to [[risperidone]].

== '''Who Should Not Use this medicine ?''' ==

This medicine cannot be used in patients who:
* are allergic to lurasidone hydrochloride or any of the ingredients in Latuda.
* are taking certain other medicines called CYP3A4 inhibitors or inducers including [[ketoconazole]], [[clarithromycin]], [[ritonavir]], [[voriconazole]], [[mibefradil]], [[rifampin]], [[avasimibe]], [[St. John's wort]], [[phenytoin]], or [[carbamazepine]].

== '''What drug interactions can this medicine cause?''' ==

* Latuda should not be used concomitantly with strong CYP3A4 inhibitors (eg:Ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil).
* Latuda dose should be reduced to half of the original level when used concomitantly with moderate inhibitors of CYP3A4 (eg:Diltiazem, atazanavir, erythromycin, fluconazole, verapamil)
* Latuda should not be used concomitantly with strong CYP3A4 inducers (eg:Rifampin, avasimibe, St. John's wort, phenytoin, carbamazepine)
* Latuda dose should be increased when used concomitantly with moderate inducers of CYP3A4 (eg:Bosentan, efavirenz, etravirine, modafinil, nafcillin)
* No dosage adjustment of Latuda is required when administered concomitantly with [[lithium]], [[valproate]], or substrates of P-gp or CYP3A4.

== '''Is this medicine FDA approved?''' ==

* Several randomized controlled trials have shown that lurasidone improves symptoms of [[schizophrenia]] and it was approved for this indication and for depressive episodes associated with [[bipolar disorder]] in the United States in 2010.

== '''How should this medicine be used?''' ==

Recommended dosage:

'''Schizophrenia'''
'''Adults:'''
* The recommended starting dose of Latuda is 40 mg once daily.
* The maximum recommended dose is 160 mg per day.

'''Adolescents (13 – 17 years):'''
* The recommended starting dose of Latuda is 40 mg once daily.
* The maximum recommended dose is 80 mg per day.

'''Depressive Episodes Associated with Bipolar I Disorder:'''
'''Adults:'''
* The recommended starting dose of Latuda is 20 mg given once daily as monotherapy or as [[adjunctive therapy]] with lithium or valproate. Initial dose titration is not required.
* The maximum recommended dose, as monotherapy or as adjunctive therapy with lithium or valproate, is 120 mg per day.

'''Pediatric Patients (10 – 17 years)'''
* The recommended starting dose of Latuda is 20 mg given once daily as monotherapy. Initial dose titration is not required. The dose may be increased after one week based on clinical response.
* The maximum recommended dose is 80 mg per day.

'''Moderate and Severe Renal Impairment:'''
* Recommended starting dose is 20 mg per day, and the maximum recommended dose is 80 mg per day.

'''Moderate and Severe Hepatic Impairment: '''
* Recommended starting dose is 20 mg per day.
* The maximum recommended dose is 80 mg per day in moderate hepatic impairment and 40 mg per day in severe hepatic impairment.

'''Concomitant Use of a Moderate CYP3A4 inhibitor (e.g., [[diltiazem]]):'''
* Latuda dose should be reduced to half of the original dose level.
* Recommended starting dose is 20 mg per day.
* Maximum recommended dose is 80 mg per day.

'''Concomitant Use of a Moderate CYP3A4 Inducer:'''
* It may be necessary to increase the dose of Latuda.

'''Administration:'''
* Take Latuda by mouth, with food (at least 350 calories).
* If you take too much Latuda, call your healthcare provider or poison control center or go to the nearest hospital emergency room right away.

== '''What are the dosage forms and brand names of this medicine?''' ==

This medicine is available in fallowing doasage form:
* '''As Tablets:''' 20 mg, 40 mg, 60 mg, 80 mg and 120 mg

This medicine is available in fallowing brand namesː
* '''Latuda'''

=='''What side effects can this medication cause?'''==

The most common side effects of this medicine include:
'''In Adults with schizophrenia:'''
* sleepiness or drowsiness
* restlessness and feeling like you need to move around ([[akathisia]])
* difficulty moving, slow movements, muscle stiffness, or [[tremor]]
* [[nausea]]

In Children 13 to 17 years of age with schizophrenia:
* sleepiness or drowsiness
* [[nausea]]
* restlessness and feeling like you need to move around ([[akathisia]])
* difficulty moving, slow movements, muscle stiffness, or [[tremor]]
* runny nose
* vomiting

In Adults with bipolar depression:
* restlessness and feeling like you need to move around (akathisia)
* difficulty moving, slow movements, muscle stiffness, or tremor
* sleepiness or drowsiness

In Children 10 to 17 years of age with bipolar depression:
* [[nausea]]
* weight gain
* problems sleeping ([[insomnia]])

Latuda may cause serious side effects, including:
* Increased risk of death in elderly people with [[dementia]]-related [[psychosis]]
* Increased risk of suicidal thoughts or actions in children and young adults
* [[tardive dyskinesia]]
* [[hyperglycemia]]
* increased fat levels ([[cholesterol]] and [[triglycerides]])
* weight gain
* [[hyperprolactinemia]]
* Low white blood cell count
* [[orthostatic hypotension]]
* [[Falls]]
* [[Seizures]] (convulsions)
* Problems controlling your body temperature so that you feel too warm
* Mania or [[hypomania]]

==''' What special precautions should I follow?''' ==

* Do not drive, operate heavy machinery, or do other dangerous activities until you know how Latuda affects you. Latuda may make you drowsy.
* Avoid eating grapefruit or drinking [[grapefruit juice]] during treatment with Latuda. Grapefruit and grapefruit juice may affect the amount of Latuda in your blood.
* Do not become too hot or dehydrated during treatment with Latuda:
* Do not exercise too much.
* In hot weather, stay inside in a cool place if possible.
* Stay out of the sun.
* Do not wear too much clothing or heavy clothing.
* Drink plenty of water.
* Elderly patients with [[dementia]]-related [[psychosis]] treated with [[antipsychotic]] drugs are at an increased risk of death. Latuda is not approved for the treatment of patients with dementia-related psychosis.
* Increased incidence of cerebrovascular adverse events (e.g., [[stroke]], [[transient ischemic attack]]) may oocur with Latuda. Latuda is not approved for the treatment of patients with dementia-related psychosis.
* A potentially fatal symptom complex sometimes referred to as [[Neuroleptic Malignant Syndrome]] (NMS) has been reported in association with administration of antipsychotic drugs, including Latuda. If NMS is suspected, immediately discontinue Latuda and provide intensive symptomatic treatment and monitoring.
* [[Tardive dyskinesia]] is a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements that can develop in patients treated with antipsychotic drugs. If signs and symptoms of tardive dyskinesia appear in a patient on Latuda, drug discontinuation should be considered.
* Atypical antipsychotic drugs have been associated with metabolic changes that may increase cardiovascular/cerebrovascular risk. Monitor for [[hyperglycemia]]/[[diabetes mellitus]], [[dyslipidemia]] and weight gain
* [[Leukopenia]]/[[neutropenia]] has been reported during treatment with antipsychotic agents. Perform complete blood counts (CBC) in patients with a pre-existing low white blood cell count (WBC) or a history of leukopenia or neutropenia. Consider discontinuing Latuda if a clinically significant decline in WBC occurs in the absence of other causative factors.
* Latuda may cause [[orthostatic hypotension]] and [[syncope]], perhaps due to its α1-adrenergic receptor antagonism. Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope.
* Latuda may cause [[somnolence]], [[postural hypotension]], motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries.

== '''What to do in case of emergency/overdose?''' ==

Symptoms of overdosage may include:
* [[arrhythmias]]
* [[Hypotension]]
* [[obtundation]]
* [[seizures]]

Management of overdosage:
* No specific [[antidote]]s for Latuda are known. In managing overdose, provide supportive care, including close medical supervision and monitoring, and consider the possibility of multiple drug involvement. If an overdose occurs, consult a Certified Poison Control Center (1-800-222-1222 or www.poison.org).
* Cardiovascular monitoring should commence immediately, including continuous [[electrocardiographic]] monitoring for possible [[arrhythmias]].
* [[Hypotension]] and [[circulatory collapse]] should be treated with appropriate measures.
* [[Gastric lavage]] (after intubation if patient is unconscious) and administration of activated charcoal together with a laxative should be considered.

== '''Can this medicine be used in pregnancy?''' ==

* There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Latuda during pregnancy. For more information, contact the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388.
* There are no studies of Latuda use in pregnant women.
* The limited available data are not sufficient to inform a drug-associated risk of birth defects or miscarriage.

=='''Can this medicine be used in children?'''==

'''Schizophrenia:'''
* The safety and effectiveness of Latuda 40-mg/day and 80-mg/day for the treatment of schizophrenia in adolescents (13 to 17 years) was established.
* The safety and effectiveness of Latuda has not been established in pediatric patients less than 13 years of age with schizophrenia.

'''Bipolar Depression:'''
* The safety and effectiveness of Latuda 20 to 80 mg/day for the treatment of [[bipolar depression]] in pediatric patients (10 to 17 years) was established.
* The safety and effectiveness of Latuda has not been established in pediatric patients less than 10 years of age with bipolar depression.

* The effectiveness of Latuda in pediatric patients for the treatment of irritability associated with [[autistic]] disorder has not been established.

== '''What are the active and inactive ingredients in this medicine?''' ==

* '''Active ingredient:''' lurasidone hydrochloride
* '''Inactive ingredients:''' mannitol, pregelatinized starch, croscarmellose sodium, hypromellose, magnesium stearate, Opadry® and carnauba wax. Additionally, the 80 mg tablet contains yellow ferric oxide and FD&C Blue No. 2 Aluminum Lake

== '''Who manufactures and distributes this medicine?''' ==

* '''Manufactured for:''' [[Sunovion Pharmaceuticals]] Inc. Marlborough, MA USA
Latuda is a registered trademark of Sumitomo Dainippon Pharma Co. Ltd.; Sunovion

== '''What should I know about storage and disposal of this medication?''' ==

* Store Latuda tablets at room temperature between 68°F to 77°F (20°C to 25°C).
* Keep Latuda and all medicines out of the reach of children.

{{antipsychotic agents}}
{{coststubd}}
{{Antipsychotics}}
{{Mood stabilizers}}
{{Navboxes
| title = [[Pharmacodynamics]]
| titlestyle = background:#ccccff
| list1 =
{{Adrenergic receptor modulators}}
{{Dopamine receptor modulators}}
{{Serotonin receptor modulators}}
}}
{{Portal bar | Medicine}}

[[Category:5-HT7 antagonists]]
[[Category:2010 introductions]]
[[Category:Alpha-2 blockers]]
[[Category:Atypical antipsychotics]]
[[Category:Benzoisothiazoles]]
[[Category:Bridged heterocyclic compounds]]
[[Category:Imides]]
[[Category:Isoindolines]]
[[Category:Lactams]]
[[Category:Mood stabilizers]]
[[Category:Piperazines]]