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2025-03-30T01:38:55Z

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Deepika vegiraju at 14:52, 3 August 2022

2022-08-03T14:52:10Z

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== '''What is Lupron Depot?''' ==

* Lupron Depot 3.75 mg([[leuprolide acetate]]) is '''a gonadotropin-releasing hormone (GnRH) agonist''' is used alone or with another medication ([[norethindrone]]) to treat [[endometriosis]] (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms).
* Leuprolide injection 3.75 mg (Lupron Depot) is also used with other medication to treat anemia (a lower than normal number of red blood cells) caused by [[uterine fibroids]] (noncancerous growths in the uterus).
* LUPRON DEPOT 7.5 mg is used for the treatment of advanced [[prostatic cancer]].

[[File:Leuprorelin.svg|thumb|Leuprorelin]]
[[File:Leuprorelin ball-and-stick.png|thumb|Leuprorelin ball-and-stick]]

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== '''What are the uses of this medicine?''' ==

* Lupron Depot 3.75 mg([[leuprolide acetate]]) is used alone or with another medication ([[norethindrone]]) to treat [[endometriosis]] (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body and causes pain, heavy or irregular menstruation [periods], and other symptoms).
* Leuprolide injection 3.75 mg(Lupron Depot) is also used with other medication to treat anemia (a lower than normal number of red blood cells) caused by [[uterine fibroids]] (noncancerous growths in the uterus).
* LUPRON DEPOT 7.5 mg is used for the treatment of advanced [[prostatic cancer]].

'''Limitations of Use:'''
* The total duration of therapy with LUPRON DEPOT 3.75 mg plus add-back therapy should not exceed 12 months due to concerns about adverse impact on [[bone mineral density]].
* LUPRON DEPOT 3.75 mg is not indicated for combination use with [[norethindrone acetate]] add-back therapy for the preoperative hematologic improvement of women with anemia caused by heavy menstrual bleeding due to [[fibroids]].

== '''How does this medicine work?''' ==

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* Leuprolide acetate is '''a long-acting GnRH analog'''.
* A single monthly injection of LUPRON DEPOT 3.75 mg results in an initial stimulation followed by a '''prolonged suppression of pituitary [[gonadotropins]]'''.
* Repeated dosing of LUPRON DEPOT 3.75 mg at monthly intervals '''results in decreased secretion of gonadal steroid'''.
* Leuprolide acetate is not active when given orally.

== '''Who Should Not Use this medicine ?''' ==

This medicine cannot be used in women with the following:
* [[Hypersensitivity]] to gonadotropin-releasing hormone (GnRH), GnRH agonist analogs, including leuprolide acetate, or any of the excipients in LUPRON DEPOT 3.75 mg
* Undiagnosed abnormal [[uterine bleeding]]
* Pregnancy

== '''What drug interactions can this medicine cause?''' ==

* No formal drug-drug interaction studies have been conducted with LUPRON DEPOT.

== '''Is this medicine FDA approved?''' ==

* Leuprorelin was patented in 1973 and approved for medical use in the United States in 1985.

== '''How should this medicine be used?''' ==

'''Recommended dosage:'''
'''Endometriosis:'''
* LUPRON DEPOT 3.75 mg administered as a single intramuscular (IM) injection once every month for up to six injections (6 months of therapy).
* LUPRON DEPOT may be administered alone or in combination with daily 5 mg tablet of norethindrone acetate (add-back).
* If endometriosis symptoms recur after initial course of therapy, retreatment for no more than six months may be considered but only with the addition of norethindrone acetate add-back therapy.
* Do not re-treat with LUPRON DEPOT 3.75 mg alone.

'''Fibroids:'''
* Recommended dose of LUPRON DEPOT 3.75 mg is one IM injection every month for up to three months.

'''Administration:'''
* LUPRON DEPOT 3.75 mg for 1-month administration, given as a single intramuscular injection.
* Do not substitute LUPRON DEPOT 3.75 mg for LUPRON DEPOT 11.25 mg.
* Do not administer LUPRON DEPOT 3.75 mg more frequently than once a month.
* Do not give a fractional dose of the LUPRON DEPOT 11.25 mg 3-month formulation, as it is not equivalent to a single dose of the LUPRON DEPOT 3.75 mg.
* Do not give a triple dose of the LUPRON DEPOT 3.75 mg, as it is not equivalent to a single dose of the LUPRON DEPOT 11.25 mg 3- month formulation.
* Reconstitute LUPRON DEPOT 3.75 mg prior to use.

== '''What are the dosage forms and brand names of this medicine?''' ==

This medicine is available in fallowing doasage form:
* As Depot suspension for injection: 3.75 mg lyophilized powder for reconstitution in a dual-chamber syringe
* As 7.5 mg, 22.5 mg, 30 mg, and 45 mg injections in a kit with prefilled dual chamber syringe.
* Depot suspension for injection: 11.25 mg lyophilized powder for reconstitution in a dual-chamber syringe.

This medicine is available in fallowing brand namesː
* '''LUPRON DEPOT'''

=='''What side effects can this medication cause?'''==

The most common side effects of this medicine include:
* [[hot flashes]]/sweats, headache/[[migraine]], [[vaginitis]], [[depression]]/emotional lability, general pain, weight gain/loss, [[nausea]]/vomiting, decreased [[libido]], and [[dizziness]]

==''' What special precautions should I follow?''' ==

* LUPRON DEPOT 3.75 mg results in loss of [[bone mineral density]] (BMD), some of which may not be reversible after stopping treatment. Duration of treatment is limited by risk of bone mineral density. When using for management of [[endometriosis]]: combination use with [[norethindrone acetate]] is effective in reducing loss of BMD; do not retreat without combination norethindrone acetate. Assess BMD before retreatment.
* LUPRON DEPOT May cause fetal harm. Exclude pregnancy before initiating treatment if clinically indicated and discontinue use if pregnancy occurs. Use non-hormonal methods of [[contraception]] only.
* [[Hypersensitivity]] reactions, including [[anaphylaxis]], have been reported with LUPRON DEPOT 3.75 mg. LUPRON DEPOT 3.75 mg is contraindicated in women with a history of hypersensitivity to gonadotropin-releasing hormone (GnRH) or GnRH agonist analogs.
* If LUPRON is administered with norethindrone acetate, the warnings and precautions for norethindrone acetate apply to the combination regimen.
* There have been postmarketing reports of convulsions in women on GnRH agonists, including leuprolide acetate. These included women with and without concurrent medications and comorbid conditions.
* [[Depression]] may occur or worsen during treatment with GnRH agonists including LUPRON DEPOT 3.75 mg. Carefully observe women for depression, especially those with a history of depression and consider whether the risks of continuing LUPRON DEPOT 3.75 mg outweigh the benefits.

== '''What to do in case of emergency/overdose?''' ==

* {{overdose}}

== '''Can this medicine be used in pregnancy?''' ==

* LUPRON DEPOT 3.75 mg is contraindicated in pregnancy.

=='''Can this medicine be used in children?'''==

* The safety and effectiveness of LUPRON DEPOT 3.75 mg for these indications have not been established in premenarcheal pediatric patients.

== '''What are the active and inactive ingredients in this medicine?''' ==

'''Active ingredient:'''
* LEUPROLIDE ACETATE

'''Inactive ingredients:'''
* ACETIC ACID
* WATER
* POLYSORBATE 80
* MANNITOL
* GELATIN, UNSPECIFIED
* CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED

== '''Who manufactures and distributes this medicine?''' ==

'''Manufactured for:'''
* [[AbbVie Inc.]]
* North Chicago, IL 60064
* by Takeda Pharmaceutical Company Limited
* Osaka, Japan

== '''What should I know about storage and disposal of this medication?''' ==

* Store between 20° to 25°C (68° to 77°F). Excursions permitted to 15° to 30°C (59° to 86°F).

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[[Category:AbbVie brands]]
[[Category:GnRH agonists]]
[[Category:Hormonal antineoplastic drugs]]
[[Category:Peptides]]
[[Category:Puberty blockers]]
[[Category:Takeda Pharmaceutical Company brands]]
[[Category:Feminizing hormone therapy]]

Lupron Depot - Revision history

Prab: CSV import

Deepika vegiraju at 14:52, 3 August 2022