https://wikimd.org/index.php?action=history&feed=atom&title=Lirequinil 2026-04-27T11:08:57Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Lirequinil&diff=6306268&oldid=prev 2025-02-17T01:55:57Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:55, 17 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l24">Line 24:</td> <td colspan="2" class="diff-lineno">Line 24:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Lirequinil_structure.png|Structure of Lirequinil</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Ro41-3290_structure.png|Structure of Ro41-3290</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=Lirequinil&diff=5299406&oldid=prev 2024-02-25T21:56:45Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Lirequinil&#039;&#039;&#039; is a [[sedative]] and [[anxiolytic]] drug that was developed by a team at [[NeuroSearch]]. It is a nonbenzodiazepine, but its structure is quite different from most other nonbenzodiazepine drugs, and it is thought to have a different mechanism of action.<br /> <br /> ==Pharmacology==<br /> Lirequinil is a [[GABA_A receptor]] partial agonist, which means it produces only a partial effect at the GABA_A receptor compared to a full agonist. This makes it less potent than full agonist drugs and may reduce the risk of side effects such as [[sedation]] and [[amnesia]].<br /> <br /> ==Development and Clinical Trials==<br /> Lirequinil was developed as a potential treatment for [[insomnia]] and [[anxiety]], but it was discontinued after Phase II [[clinical trials]] due to poor results. The drug was found to be less effective than other treatments for insomnia, and it had a higher rate of side effects.<br /> <br /> ==Side Effects==<br /> The most common side effects of Lirequinil include [[dizziness]], [[nausea]], and [[headache]]. Some patients also reported feeling [[fatigue]]d or [[sleepy]] during the day. These side effects were more common in patients taking higher doses of the drug.<br /> <br /> ==See Also==<br /> * [[Nonbenzodiazepine]]<br /> * [[GABA_A receptor]]<br /> * [[Clinical trial]]<br /> * [[Insomnia]]<br /> * [[Anxiety]]<br /> <br /> [[Category:Drugs]]<br /> [[Category:Sedatives]]<br /> [[Category:Anxiolytics]]<br /> [[Category:GABA_A receptor agonists]]<br /> [[Category:Abandoned drugs]]<br /> <br /> {{stub}}</div>

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