Linear verrucous epidermal nevus - Revision history

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2025-04-08T01:13:47Z

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			{{SI}}
			{{Infobox medical condition
			\| name = Linear verrucous epidermal nevus
			\| image = [[File:SkinTumors-P5280048.JPG\|left\|thumb\|Linear verrucous epidermal nevus]]
			\| caption = Linear verrucous epidermal nevus on the skin
			\| synonyms = Verrucous epidermal nevus
			\| field = [[Dermatology]]
			\| symptoms = [[Wart]]-like lesions, [[hyperkeratosis]], [[pruritus]]
			\| complications = [[Secondary infection]], [[malignant transformation]]
			\| onset = [[Childhood]]
			\| duration = [[Chronic (medicine)\|Chronic]]
			\| causes = [[Genetic mutation]]
			\| risks = [[Genetic predisposition]]
			\| diagnosis = [[Clinical diagnosis]], [[skin biopsy]]
			\| differential = [[Verrucous carcinoma]], [[psoriasis]], [[lichen planus]]
			\| treatment = [[Topical treatment]], [[surgical excision]], [[laser therapy]]
			\| medication = [[Keratolytics]], [[retinoids]]
			\| frequency = Rare
			}}
	{{Short description\|A type of skin lesion}}		{{Short description\|A type of skin lesion}}
	~~{{Use dmy dates\|date=October 2023}}~~

	'''Linear verrucous epidermal nevus''' (LVEN) is a type of [[epidermal nevus]] characterized by a linear arrangement of [[verrucous]] skin lesions. These lesions are typically present at birth or develop in early childhood and are caused by a genetic mosaicism.		'''Linear verrucous epidermal nevus''' (LVEN) is a type of [[epidermal nevus]] characterized by a linear arrangement of [[verrucous]] skin lesions. These lesions are typically present at birth or develop in early childhood and are caused by a genetic mosaicism.

	==Presentation==		==Presentation==
	~~[[File:SkinTumors-P5280048.JPG\|thumb\|right\|Linear verrucous epidermal nevus on the arm]]~~
	Linear verrucous epidermal nevus presents as a series of [[hyperkeratotic]] and [[verrucous]] papules that coalesce into linear plaques. These lesions follow the lines of [[Blaschko's lines]], which are patterns of skin cell development. The lesions are often [[hyperpigmented]] and can vary in color from light brown to dark brown or black.		Linear verrucous epidermal nevus presents as a series of [[hyperkeratotic]] and [[verrucous]] papules that coalesce into linear plaques. These lesions follow the lines of [[Blaschko's lines]], which are patterns of skin cell development. The lesions are often [[hyperpigmented]] and can vary in color from light brown to dark brown or black.

	==Pathophysiology==		==Pathophysiology==
	LVEN is caused by a postzygotic mutation leading to genetic mosaicism. This results in a localized area of skin cells that proliferate abnormally, forming the characteristic lesions. The exact genetic mutations involved can vary, but they often affect genes related to skin cell growth and differentiation.		LVEN is caused by a postzygotic mutation leading to genetic mosaicism. This results in a localized area of skin cells that proliferate abnormally, forming the characteristic lesions. The exact genetic mutations involved can vary, but they often affect genes related to skin cell growth and differentiation.

	==Diagnosis==		==Diagnosis==
	Diagnosis of linear verrucous epidermal nevus is primarily clinical, based on the appearance and distribution of the lesions. A [[skin biopsy]] may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show [[acanthosis]], [[hyperkeratosis]], and papillomatosis.		Diagnosis of linear verrucous epidermal nevus is primarily clinical, based on the appearance and distribution of the lesions. A [[skin biopsy]] may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show [[acanthosis]], [[hyperkeratosis]], and papillomatosis.

	==Management==		==Management==
	Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include:		Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include:
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	* [[Laser therapy]]		* [[Laser therapy]]
	* [[Surgical excision]]		* [[Surgical excision]]

	==Prognosis==		==Prognosis==
	The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, there is a small risk of [[malignant transformation]] in long-standing lesions, so regular monitoring is recommended.		The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, there is a small risk of [[malignant transformation]] in long-standing lesions, so regular monitoring is recommended.
			==See also==
	==~~Related pages~~==
	* [[Epidermal nevus]]		* [[Epidermal nevus]]
	* [[Blaschko's lines]]		* [[Blaschko's lines]]
	* [[Genetic mosaicism]]		* [[Genetic mosaicism]]

	[[Category:Dermatology]]		[[Category:Dermatology]]
	[[Category:Skin conditions resulting in tumors]]		[[Category:Skin conditions resulting in tumors]]

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Management

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	==Management==		==Management==
	~~[[File:Verrucous_epid_nevus.jpg\|thumb\|left\|Close-up of verrucous epidermal nevus]]~~
	Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include:		Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include:
	* [[Topical treatments]] such as [[keratolytics]] or [[retinoids]]		* [[Topical treatments]] such as [[keratolytics]] or [[retinoids]]

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	~~'''Linear verrucous epidermal nevus''' (LVEN) is a rare~~ skin ~~condition characterized by the presence of well-demarcated, linear, verrucous (wart-like) plaques that follow the lines of [[Blaschko's lines~~\|Blaschko]]. These lesions are benign but can be associated with significant cosmetic concerns and, in some cases, other systemic manifestations. The condition is congenital, meaning it is present at birth, but may not become apparent until later in childhood or even adulthood.		{{Short description\|A type of skin lesion}}
			{{Use dmy dates\|date=October 2023}}

	~~==Etiology and Pathogenesis==~~		'''Linear verrucous epidermal nevus''' (LVEN) is a type of [[epidermal nevus]] characterized by a linear arrangement of [[verrucous]] skin lesions. These lesions are typically present at birth or develop in early childhood and are caused by a genetic mosaicism.
	~~The exact cause of linear~~ verrucous epidermal nevus is ~~not fully understood. It is believed to result from somatic mutations that occur during embryonic development, leading to mosaicism. These mutations affect the normal development~~ of ~~the~~ [[~~epidermis~~]]~~, resulting in the characteristic lesions. Unlike other forms~~ of [[~~epidermal nevus syndrome~~]]~~, LVEN is not~~ typically ~~associated with systemic abnormalities~~.

	==~~Clinical Features~~==		==Presentation==
	Linear verrucous epidermal nevus ~~typically~~ presents as ~~skin-colored to brown,~~ verrucous ~~(wart-like),~~ linear plaques. These ~~plaques strictly~~ follow the lines of Blaschko, which are ~~invisible lines on the~~ skin ~~representing pathways of embryonic~~ cell ~~migration~~. The lesions can vary in ~~size and thickness and are most commonly found on the trunk and extremities~~. ~~Although~~ LVEN is ~~usually asymptomatic~~, lesions can ~~become irritated or infected~~, ~~leading~~ to ~~discomfort~~.		[[File:SkinTumors-P5280048.JPG\|thumb\|right\|Linear verrucous epidermal nevus on the arm]]
			Linear verrucous epidermal nevus presents as a series of [[hyperkeratotic]] and [[verrucous]] papules that coalesce into linear plaques. These lesions follow the lines of [[Blaschko's lines]], which are patterns of skin cell development. The lesions are often [[hyperpigmented]] and can vary in color from light brown to dark brown or black.

			==Pathophysiology==
			LVEN is caused by a postzygotic mutation leading to genetic mosaicism. This results in a localized area of skin cells that proliferate abnormally, forming the characteristic lesions. The exact genetic mutations involved can vary, but they often affect genes related to skin cell growth and differentiation.

	==Diagnosis==		==Diagnosis==
	~~The diagnosis~~ of linear verrucous epidermal nevus is primarily clinical, based on the ~~characteristic~~ appearance and distribution of the lesions. ~~In uncertain cases, a~~ [[skin biopsy]] may be performed to confirm the diagnosis. Histologically, ~~LVEN shows~~ hyperkeratosis, papillomatosis~~, and acanthosis, which are typical features of verrucous epidermal nevi~~.		Diagnosis of linear verrucous epidermal nevus is primarily clinical, based on the appearance and distribution of the lesions. A [[skin biopsy]] may be performed to confirm the diagnosis and rule out other conditions. Histologically, the lesions show [[acanthosis]], [[hyperkeratosis]], and papillomatosis.

	==~~Treatment~~==		==Management==
	~~There is no cure for linear~~ verrucous epidermal nevus, ~~and~~ treatment ~~is aimed at managing symptoms and improving~~ cosmetic ~~appearance~~. Options include ~~topical~~ treatments, such as [[~~retinoids~~]] ~~and~~ [[~~keratolytics~~]]~~, and procedural interventions like~~ [[~~laser therapy~~]], [[~~cryotherapy~~]]~~, and~~ [[~~surgical~~ excision]]~~. The choice of treatment depends on the extent and location of the lesions, as well as the patient's preferences and tolerance for potential side effects.~~		[[File:Verrucous_epid_nevus.jpg\|thumb\|left\|Close-up of verrucous epidermal nevus]]
			Management of LVEN is often conservative, as the lesions are benign. However, treatment may be sought for cosmetic reasons or if the lesions become symptomatic. Options include:
			* [[Topical treatments]] such as [[keratolytics]] or [[retinoids]]
			* [[Cryotherapy]]
			* [[Laser therapy]]
			* [[Surgical excision]]

	==Prognosis==		==Prognosis==
	The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, ~~the cosmetic appearance~~ of ~~the~~ lesions ~~can be a significant concern for affected individuals~~, ~~potentially leading to psychological distress. Regular follow-up with a dermatologist~~ is recommended ~~to monitor for any changes in the lesions and to manage any associated symptoms~~.		The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, there is a small risk of [[malignant transformation]] in long-standing lesions, so regular monitoring is recommended.

	==~~See Also~~==		==Related pages==
	* [[Epidermal nevus ~~syndrome~~]]		* [[Epidermal nevus]]
	* [[Blaschko's lines]]		* [[Blaschko's lines]]
	* [[~~Skin biopsy~~]]		* [[Genetic mosaicism]]

	[[Category:Dermatology]]		[[Category:Dermatology]]
	~~[[Category:Congenital disorders]]~~		[[Category:Skin conditions resulting in tumors]]
	[[Category:Skin conditions]]

	~~{{Medicine-stub}}~~
	~~<gallery caption="Linear verrucous epidermal nevus">~~
	~~File:SkinTumors-P5280048.JPG\|Linear verrucous epidermal nevus~~
	~~File:Verrucous epid nevus.jpg\|Linear verrucous epidermal nevus~~
	~~</gallery>~~

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	{{Medicine-stub}}		{{Medicine-stub}}
			<gallery caption="Linear verrucous epidermal nevus">
			File:SkinTumors-P5280048.JPG\|Linear verrucous epidermal nevus
			File:Verrucous epid nevus.jpg\|Linear verrucous epidermal nevus
			</gallery>

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Linear verrucous epidermal nevus

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	{{Medicine-stub}}		{{Medicine-stub}}
	~~== Linear verrucous epidermal nevus ==~~
	~~<gallery>~~
	~~File:Verrucous_epid_nevus.jpg~~
	~~</gallery>~~

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	{{Medicine-stub}}		{{Medicine-stub}}
			== Linear verrucous epidermal nevus ==
			<gallery>
			File:Verrucous_epid_nevus.jpg
			</gallery>

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2024-03-22T10:57:36Z

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New page

'''Linear verrucous epidermal nevus''' (LVEN) is a rare skin condition characterized by the presence of well-demarcated, linear, verrucous (wart-like) plaques that follow the lines of [[Blaschko's lines|Blaschko]]. These lesions are benign but can be associated with significant cosmetic concerns and, in some cases, other systemic manifestations. The condition is congenital, meaning it is present at birth, but may not become apparent until later in childhood or even adulthood.

==Etiology and Pathogenesis==
The exact cause of linear verrucous epidermal nevus is not fully understood. It is believed to result from somatic mutations that occur during embryonic development, leading to mosaicism. These mutations affect the normal development of the [[epidermis]], resulting in the characteristic lesions. Unlike other forms of [[epidermal nevus syndrome]], LVEN is not typically associated with systemic abnormalities.

==Clinical Features==
Linear verrucous epidermal nevus typically presents as skin-colored to brown, verrucous (wart-like), linear plaques. These plaques strictly follow the lines of Blaschko, which are invisible lines on the skin representing pathways of embryonic cell migration. The lesions can vary in size and thickness and are most commonly found on the trunk and extremities. Although LVEN is usually asymptomatic, lesions can become irritated or infected, leading to discomfort.

==Diagnosis==
The diagnosis of linear verrucous epidermal nevus is primarily clinical, based on the characteristic appearance and distribution of the lesions. In uncertain cases, a [[skin biopsy]] may be performed to confirm the diagnosis. Histologically, LVEN shows hyperkeratosis, papillomatosis, and acanthosis, which are typical features of verrucous epidermal nevi.

==Treatment==
There is no cure for linear verrucous epidermal nevus, and treatment is aimed at managing symptoms and improving cosmetic appearance. Options include topical treatments, such as [[retinoids]] and [[keratolytics]], and procedural interventions like [[laser therapy]], [[cryotherapy]], and [[surgical excision]]. The choice of treatment depends on the extent and location of the lesions, as well as the patient's preferences and tolerance for potential side effects.

==Prognosis==
The prognosis for individuals with linear verrucous epidermal nevus is generally good, as the condition is benign. However, the cosmetic appearance of the lesions can be a significant concern for affected individuals, potentially leading to psychological distress. Regular follow-up with a dermatologist is recommended to monitor for any changes in the lesions and to manage any associated symptoms.

==See Also==
* [[Epidermal nevus syndrome]]
* [[Blaschko's lines]]
* [[Skin biopsy]]

[[Category:Dermatology]]
[[Category:Congenital disorders]]
[[Category:Skin conditions]]

{{Medicine-stub}}