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[[File:Lincomycin.png|thumb|{{PAGENAME}}]]<br>'''Lincomycin''' is an [[antibiotic]] used in the treatment of [[bacterial infections]]. It is a lincosamide antibiotic, derived from the actinobacterium ''[[Streptomyces lincolnensis]]''. Lincomycin is predominantly used against [[Gram-positive bacteria]], and is particularly effective against [[Staphylococcus]], [[Streptococcus]], and [[Bacteroides]] species.

== History ==

Lincomycin was first isolated in 1962 from a soil sample collected in [[Lincoln, Nebraska]]. The discovery of lincomycin led to the development of a semi-synthetic derivative, [[clindamycin]], which has since become more commonly used due to its improved properties.

== Mechanism of Action ==

Lincomycin works by inhibiting [[protein synthesis]] in susceptible bacteria. It binds to the 50S subunit of the bacterial [[ribosome]], preventing the addition of new [[amino acids]] to the growing peptide chain.

== Side Effects ==

Common side effects of lincomycin include [[nausea]], [[vomiting]], [[diarrhea]], and [[rash]]. More serious side effects can include [[Clostridium difficile-associated diarrhea]], [[allergic reactions]], and [[blood disorders]].

== Resistance ==

Resistance to lincomycin can occur through several mechanisms, including modification of the antibiotic target, active efflux of the drug, and enzymatic inactivation of the drug. The most common mechanism of resistance is through [[methylation]] of the 23S ribosomal RNA, which prevents lincomycin from binding to the ribosome.

== See Also ==

* [[Clindamycin]]
* [[Lincosamides]]
* [[Antibiotic resistance]]

[[Category:Antibiotics]]
[[Category:Lincosamides]]
{{Antibiotics-stub}}

Lincomycin - Revision history

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