https://wikimd.com/index.php?action=history&feed=atom&title=LignanLignan - Revision history2026-04-23T03:24:54ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=Lignan&diff=5831704&oldid=prevPrab: CSV import2024-05-27T01:39:00Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Matairesinol.png|thumb|Matairesinol|right]] [[File:Secoisolariciresinol Structural Formula V.1.svg|thumb|Secoisolariciresinol Structural Formula V.1|left]] [[File:Justicidin A.svg|thumb|Justicidin A.svg]] [[File:Pinoresinol.svg|thumb|Pinoresinol|right]] [[File:Steganacin.svg|thumb|Steganacin|right]] [[File:Podophyllotoxin2DCSD.svg|thumb|Podophyllotoxin2DCSD|right]] '''Lignan''' is a group of chemical compounds found in plants, particularly in seeds, whole grains, vegetables, and fruits. They are classified as [[phytoestrogens]], which are plant-derived compounds with estrogenic activity. Lignans are one of the major classes of [[phytoestrogens]], the other being [[isoflavones]].<br />
==Structure and Biosynthesis==<br />
Lignans are derived from [[phenylpropanoids]] and are formed by the dimerization of two [[cinnamic acid]] residues. The biosynthesis of lignans involves the enzyme [[phenylalanine ammonia-lyase]] (PAL), which converts [[phenylalanine]] to [[cinnamic acid]]. This is followed by a series of enzymatic reactions that lead to the formation of various lignan structures.<br />
==Types of Lignans==<br />
There are several types of lignans, including:<br />
* [[Secoisolariciresinol diglucoside]] (SDG)<br />
* [[Matairesinol]]<br />
* [[Pinoresinol]]<br />
* [[Lariciresinol]]<br />
==Sources of Lignans==<br />
Lignans are found in a variety of plant-based foods. Some of the richest sources include:<br />
* [[Flaxseeds]]<br />
* [[Sesame seeds]]<br />
* [[Whole grains]]<br />
* [[Brassica vegetables]] (such as [[broccoli]] and [[cabbage]])<br />
* [[Berries]]<br />
==Health Benefits==<br />
Lignans have been studied for their potential health benefits, which include:<br />
* [[Antioxidant]] properties<br />
* [[Anti-inflammatory]] effects<br />
* Potential to reduce the risk of [[cardiovascular disease]]<br />
* Potential to reduce the risk of certain types of [[cancer]], particularly [[breast cancer]] and [[prostate cancer]]<br />
==Metabolism==<br />
Once ingested, lignans are metabolized by the [[gut microbiota]] into enterolignans, such as [[enterodiol]] and [[enterolactone]]. These metabolites are believed to be responsible for many of the health benefits associated with lignan consumption.<br />
==Research and Studies==<br />
Ongoing research is investigating the role of lignans in human health, particularly their potential in preventing and treating chronic diseases. Studies have shown that higher intake of lignans is associated with a lower risk of [[breast cancer]] and improved [[cardiovascular health]].<br />
==See Also==<br />
* [[Phytoestrogen]]<br />
* [[Isoflavone]]<br />
* [[Phenylpropanoid]]<br />
* [[Flaxseed]]<br />
* [[Antioxidant]]<br />
==References==<br />
{{Reflist}}<br />
==External Links==<br />
{{Commons category|Lignans}}<br />
[[Category:Phytoestrogens]]<br />
[[Category:Phenylpropanoids]]<br />
[[Category:Antioxidants]]<br />
[[Category:Plant physiology]]<br />
{{medicine-stub}}</div>Prab