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<p><b>New page</b></p><div>[[File:Lerisetron.png|thumb|{{PAGENAME}}]]<br>'''Lerisetron''' is a [[pharmacological]] agent that is classified as a [[5-HT3 antagonist]]. It is primarily used in the prevention and treatment of [[chemotherapy]]-induced [[nausea]] and [[vomiting]] (CINV). <br />
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==Pharmacology==<br />
[[Lerisetron]] works by blocking the action of [[serotonin]], a natural substance that may cause nausea and vomiting. It is a potent and selective [[5-HT3 receptor]] antagonist. The 5-HT3 receptors are located on the nerve terminals of the [[vagus nerve]] in the periphery, and centrally in the [[chemoreceptor trigger zone]] of the area postrema. <br />
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==Clinical Use==<br />
[[Lerisetron]] is used to prevent nausea and vomiting caused by cancer chemotherapy. It is used in combination with other medications to prevent delayed nausea and vomiting that may occur a few days after receiving chemotherapy treatment. <br />
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==Side Effects==<br />
Common side effects of [[Lerisetron]] include headache, constipation, and fatigue. Serious side effects may include [[Serotonin Syndrome]], a potentially life-threatening condition that can occur with the use of 5-HT3 receptor antagonists.<br />
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==History==<br />
[[Lerisetron]] was developed by [[Helsinn Healthcare]], a Swiss pharmaceutical company, in the late 1990s. It was approved for medical use in Europe in 1997, but is not currently approved for use in the United States.<br />
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==See Also==<br />
* [[5-HT3 antagonist]]<br />
* [[Chemotherapy-induced nausea and vomiting]]<br />
* [[Serotonin Syndrome]]<br />
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[[Category:Pharmacology]]<br />
[[Category:5-HT3 antagonists]]<br />
[[Category:Anti-emetics]]<br />
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{{5-HT3 antagonist-stub}}<br />
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