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<p><b>New page</b></p><div>[[File:LY294002.svg|thumb|{{PAGENAME}}]]<br>'''LY294002''' is a [[molecule]] that acts as a specific [[inhibitor]] of [[phosphoinositide 3-kinases]] (PI3Ks). It was first synthesized and studied by scientists at the [[Eli Lilly and Company]] in the 1990s. LY294002 has been widely used in [[cell biology]] and [[cancer research]] to understand the role of PI3Ks and the [[PI3K/AKT/mTOR pathway]] in cell growth, proliferation, and survival.<br />
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==Chemistry==<br />
LY294002 is a synthetic molecule that belongs to the class of [[morpholine]] derivatives. It is a [[quinoline]] derivative with a morpholine ring attached to the quinoline nucleus at the 4-position. The chemical formula of LY294002 is C19H17NO3.<br />
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==Mechanism of Action==<br />
LY294002 inhibits PI3Ks by binding to the ATP-binding pocket of these enzymes, thereby preventing the phosphorylation of [[phosphatidylinositol]] (4,5)-bisphosphate (PIP2) to phosphatidylinositol (3,4,5)-trisphosphate (PIP3). This inhibition disrupts the activation of [[AKT]], a downstream effector of PI3K, and thus blocks the PI3K/AKT/mTOR pathway.<br />
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==Applications in Research==<br />
LY294002 has been extensively used in research to study the role of the PI3K/AKT/mTOR pathway in various biological processes and diseases. It has been particularly useful in cancer research, where the PI3K/AKT/mTOR pathway is often dysregulated. By using LY294002, researchers have been able to elucidate the roles of this pathway in cell growth, proliferation, survival, and [[apoptosis]].<br />
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==Safety and Toxicity==<br />
While LY294002 is a valuable tool in research, it is not suitable for use in humans due to its toxicity. It has been found to cause liver damage in animal studies. Therefore, the use of LY294002 is limited to in vitro and animal studies.<br />
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==See Also==<br />
* [[Phosphoinositide 3-kinase]]<br />
* [[PI3K/AKT/mTOR pathway]]<br />
* [[Cancer research]]<br />
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[[Category:Chemical compounds]]<br />
[[Category:Biochemistry]]<br />
[[Category:Cell biology]]<br />
[[Category:Cancer research]]<br />
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