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LRP3 - Revision history
2026-04-21T18:54:28Z
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<p><b>New page</b></p><div>'''LRP3''' or '''Low-density lipoprotein receptor-related protein 3''' is a protein that in humans is encoded by the LRP3 gene. The LRP3 gene is located on chromosome 19 in humans. The protein encoded by this gene is a member of the LDL receptor family, which are cell surface proteins involved in receptor-mediated endocytosis of specific ligands.<br />
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== Function ==<br />
LRP3 is a member of the [[Low-density lipoprotein receptor family|LDL receptor family]], which are cell surface proteins involved in receptor-mediated endocytosis of specific ligands. These proteins play a critical role in the control of cholesterol homeostasis. The LRP3 protein is thought to play a role in the cellular uptake of cholesterol and lipids.<br />
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== Clinical significance ==<br />
Mutations in the LRP3 gene have been associated with various diseases, including [[Hypercholesterolemia|hypercholesterolemia]], [[Atherosclerosis|atherosclerosis]], and [[Coronary artery disease|coronary artery disease]]. Further research is needed to fully understand the role of LRP3 in these conditions.<br />
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== See also ==<br />
* [[Low-density lipoprotein receptor family]]<br />
* [[Hypercholesterolemia]]<br />
* [[Atherosclerosis]]<br />
* [[Coronary artery disease]]<br />
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== References ==<br />
<references /><br />
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[[Category:Genes on human chromosome 19]]<br />
[[Category:LDL receptor family]]<br />
[[Category:Human proteins]]<br />
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