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<p>CSV import</p> <p><b>New page</b></p><div>[[File:Kasugamycin.png|thumb|{{PAGENAME}}]]&lt;br&gt;&#039;&#039;&#039;Kasugamycin&#039;&#039;&#039; is an [[aminoglycoside]] [[antibiotic]] that was first isolated from &#039;&#039;[[Streptomyces kasugaensis]]&#039;&#039; in 1965. It is primarily used in the treatment of [[plant diseases]], particularly those caused by [[bacteria]] and [[fungi]]. <br /> <br /> == History ==<br /> <br /> Kasugamycin was discovered by researchers at the [[Kasuga Laboratory]] in Japan. The antibiotic was named after the laboratory and the species of bacteria from which it was isolated. <br /> <br /> == Structure and Mechanism of Action ==<br /> <br /> Kasugamycin is a unique aminoglycoside in that it contains a [[hexose]] ring, unlike the typical aminoglycosides which contain a [[deoxystreptamine]] ring. This structural difference is believed to contribute to its unique mechanism of action.<br /> <br /> Kasugamycin inhibits [[protein synthesis]] by binding to the [[30S ribosomal subunit]], preventing the formation of the [[initiation complex]]. This inhibits the [[translation]] process, thereby preventing the bacteria from producing essential proteins and ultimately leading to their death.<br /> <br /> == Uses ==<br /> <br /> Kasugamycin is primarily used in [[agriculture]] to control bacterial and fungal diseases in plants. It is particularly effective against [[rice blast]], a major disease affecting rice crops worldwide. It is also used to treat [[fire blight]] in apple and pear trees.<br /> <br /> In addition to its use in agriculture, kasugamycin has also been investigated for its potential use in human medicine. However, its use in this area is currently limited due to concerns about potential [[toxicity]] and the development of [[antibiotic resistance]].<br /> <br /> == Safety and Resistance ==<br /> <br /> Like all antibiotics, the use of kasugamycin can lead to the development of antibiotic resistance. This is a major concern in both agriculture and human medicine. To mitigate this risk, it is important to use kasugamycin judiciously and to rotate it with other types of antibiotics.<br /> <br /> In terms of safety, kasugamycin is generally considered to be safe for use in agriculture. However, as with all pesticides, it is important to follow the manufacturer&#039;s instructions to minimize any potential risks.<br /> <br /> == See Also ==<br /> <br /> * [[Aminoglycoside]]<br /> * [[Antibiotic resistance]]<br /> * [[Rice blast]]<br /> * [[Fire blight]]<br /> <br /> == References ==<br /> <br /> {{reflist}}<br /> <br /> [[Category:Antibiotics]]<br /> [[Category:Aminoglycosides]]<br /> [[Category:Agricultural chemicals]]<br /> [[Category:Pharmacology]]<br /> {{pharmacology-stub}}</div>

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