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KRT81 - Revision history
2026-04-26T00:42:01Z
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2025-03-17T16:10:53Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:10, 17 March 2025</td>
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2025-02-11T02:32:16Z
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2024-02-29T05:51:37Z
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<p><b>New page</b></p><div>'''KRT81''' (also known as '''Keratin 81''') is a type of [[keratin]] protein that is encoded in humans by the '''KRT81''' gene. It is a member of the [[keratin family]], which is a group of fibrous structural proteins that form the main component of hair, nails, and the outer layer of skin.<br />
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== Function ==<br />
KRT81 is a type of [[intermediate filament]] protein that provides structural support to cells. It is specifically involved in the formation of hair shafts, contributing to the strength and resilience of hair. Mutations in the KRT81 gene can lead to [[Monilethrix]], a rare genetic condition characterized by beaded or brittle hair.<br />
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== Structure ==<br />
The KRT81 protein is a type of [[Type II keratin]], which means it is a basic or neutral protein. It forms a complex with [[Type I keratin]] to create the intermediate filaments in hair cells. The structure of KRT81 is characterized by a central alpha-helical rod domain, flanked by non-helical head and tail domains.<br />
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== Clinical significance ==<br />
Mutations in the KRT81 gene can cause [[Monilethrix]], a condition characterized by abnormal hair shafts and hair loss. This condition is inherited in an [[autosomal dominant]] manner. There is currently no cure for Monilethrix, but treatments can help manage the symptoms.<br />
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== See also ==<br />
* [[Keratin]]<br />
* [[Monilethrix]]<br />
* [[Intermediate filament]]<br />
* [[Type I keratin]]<br />
* [[Type II keratin]]<br />
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== References ==<br />
<references /><br />
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[[Category:Proteins]]<br />
[[Category:Genes]]<br />
[[Category:Human proteins]]<br />
[[Category:Keratins]]<br />
{{Protein-stub}}<br />
{{Gene-stub}}</div>
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