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	'''KRT80''' also known as '''Keratin 80''' is a type of [[keratin]] protein that is encoded in humans by the KRT80 gene. It is a member of the [[keratin family]], which is a group of fibrous structural proteins that form the main component of the [[epithelial cells]], which are cells that line the surfaces of the body.

	== ~~Structure~~ ==		{{Infobox protein
	KRT80 is a type I keratin~~, which means it is an acidic~~ protein~~. It~~ is ~~characterized~~ by ~~its unique structure, which consists~~ of ~~a central~~ [[~~alpha-helix~~]] ~~domain flanked by non-helical head~~ and ~~tail domains. The alpha-helix domain is responsible for~~ the ~~coiled-coil structure that is characteristic~~ of ~~keratins~~.		\| name = Keratin 80
			\| symbol = KRT80
			\| image = <!-- Image of the protein, if available -->
			\| width =
			\| caption =
			\| HGNCid = 28912
			\| OMIM = 617927
			\| RefSeq = NM_181609
			\| UniProt = Q9BYR8
			}}

			'''Keratin 80''' ('''KRT80''') is a type of [[keratin]] protein that is encoded by the '''KRT80''' gene in humans. Keratins are a family of fibrous structural proteins that are key components of the [[cytoskeleton]] of epithelial cells. They provide mechanical support and play a crucial role in the protection and integrity of epithelial tissues.

	== Function ==		== Function ==
	KRT80 ~~plays a crucial role in maintaining the structural integrity of epithelial cells. It provides mechanical support to the cells, which~~ is ~~particularly important~~ in ~~tissues that are subject to constant physical stress, such as~~ the ~~skin,~~ hair, and ~~nails. In addition to its structural role, KRT80~~ is ~~also~~ involved ~~in several cellular processes, including cell growth, differentiation, and migration.~~		KRT80 is primarily expressed in the [[hair follicle]] and is involved in the formation of the [[hair shaft]]. It is a type II keratin, which typically pairs with type I keratins to form intermediate filaments. These filaments are essential for the structural integrity and resilience of hair fibers.

	~~== Clinical significance ==~~
	~~Mutations~~ in the ~~KRT80 gene have been associated with a variety~~ of ~~human diseases, including~~ [[~~ichthyosis~~]]~~, a group of skin disorders characterized by dry, scaly skin~~. ~~In particular, a specific mutation in the KRT80 gene has been linked to~~ a ~~rare form of ichthyosis known as ichthyosis hystrix.~~

	~~== Research ==~~
	~~Research on KRT80 is ongoing~~, with ~~scientists seeking~~ to ~~better understand its role in health and disease~~. ~~This includes studying~~ the ~~effects~~ of ~~KRT80 mutations on cell function, as well as exploring potential therapeutic strategies for diseases associated with KRT80 mutations~~.

	[[~~File:Keratin 80.jpg\|thumb\|right\|Keratin 80 protein structure~~]]		== Clinical Significance ==
			Mutations in the KRT80 gene have been associated with certain [[hair disorders]], including [[monilethrix]], a condition characterized by beaded or fragile hair. Understanding the role of KRT80 in hair biology can provide insights into the mechanisms underlying these conditions and potentially lead to targeted therapies.

	== See ~~also~~ ==		== See Also ==
	* [[Keratin]]		* [[Keratin]]
	* [[~~Keratin family~~]]		* [[Cytoskeleton]]
	* [[~~Ichthyosis~~]]		* [[Hair follicle]]
	* [[~~Epithelial cells~~]]		* [[Monilethrix]]

	== References ==		== References ==
	<references />		<references />

			{{Protein-stub}}

			[[Category:Keratins]]
	[[Category:Proteins]]		[[Category:Proteins]]
	[[Category:Genes]]		[[Category:Genes on human chromosome 12]]
	[[Category:~~Human proteins~~]]		[[Category:Hair diseases]]
	~~[[Category:Keratins]]~~
	~~{{protein-stub}}~~
	~~{{medicine-stub}}~~

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'''KRT80''' also known as '''Keratin 80''' is a type of [[keratin]] protein that is encoded in humans by the KRT80 gene. It is a member of the [[keratin family]], which is a group of fibrous structural proteins that form the main component of the [[epithelial cells]], which are cells that line the surfaces of the body.

== Structure ==
KRT80 is a type I keratin, which means it is an acidic protein. It is characterized by its unique structure, which consists of a central [[alpha-helix]] domain flanked by non-helical head and tail domains. The alpha-helix domain is responsible for the coiled-coil structure that is characteristic of keratins.

== Function ==
KRT80 plays a crucial role in maintaining the structural integrity of epithelial cells. It provides mechanical support to the cells, which is particularly important in tissues that are subject to constant physical stress, such as the skin, hair, and nails. In addition to its structural role, KRT80 is also involved in several cellular processes, including cell growth, differentiation, and migration.

== Clinical significance ==
Mutations in the KRT80 gene have been associated with a variety of human diseases, including [[ichthyosis]], a group of skin disorders characterized by dry, scaly skin. In particular, a specific mutation in the KRT80 gene has been linked to a rare form of ichthyosis known as ichthyosis hystrix.

== Research ==
Research on KRT80 is ongoing, with scientists seeking to better understand its role in health and disease. This includes studying the effects of KRT80 mutations on cell function, as well as exploring potential therapeutic strategies for diseases associated with KRT80 mutations.

[[File:Keratin 80.jpg|thumb|right|Keratin 80 protein structure]]

== See also ==
* [[Keratin]]
* [[Keratin family]]
* [[Ichthyosis]]
* [[Epithelial cells]]

== References ==
<references />

[[Category:Proteins]]
[[Category:Genes]]
[[Category:Human proteins]]
[[Category:Keratins]]
{{protein-stub}}
{{medicine-stub}}

KRT80 - Revision history

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