https://wikimd.org/index.php?action=history&feed=atom&title=KDM4AKDM4A - Revision history2026-04-25T13:11:35ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=KDM4A&diff=6511149&oldid=prevPrab: CSV import2025-03-17T16:10:04Z<p>CSV import</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 16:10, 17 March 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l29">Line 29:</td>
<td colspan="2" class="diff-lineno">Line 29:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr>
</table>Prabhttps://wikimd.org/index.php?title=KDM4A&diff=6266097&oldid=prevPrab: CSV import2025-02-11T00:33:23Z<p>CSV import</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 00:33, 11 February 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l28">Line 28:</td>
<td colspan="2" class="diff-lineno">Line 28:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Human proteins]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Human proteins]]</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Medicine-stub}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr>
</table>Prabhttps://wikimd.org/index.php?title=KDM4A&diff=5408615&oldid=prevPrab: CSV import2024-03-19T05:35:11Z<p>CSV import</p>
<p><b>New page</b></p><div>'''KDM4A''', also known as '''Lysine Demethylase 4A''', is a [[protein]] that in humans is encoded by the ''KDM4A'' gene. This enzyme is part of the Jumonji domain-containing (JmjC) family of demethylases, which are involved in the demethylation of [[Histone|histones]], thus playing a crucial role in [[Epigenetics|epigenetic]] regulation and [[Gene expression|gene expression]].<br />
<br />
== Function ==<br />
KDM4A specifically demethylates lysine 9 and lysine 36 residues on histone H3 (H3K9me3/2 and H3K36me3/2), thereby acting as a key regulator in the modification of chromatin structure. This modification can either activate or repress gene expression depending on the context within which it occurs. By altering histone methylation marks, KDM4A influences various biological processes including [[DNA repair]], [[Cell cycle|cell cycle progression]], and [[Apoptosis|apoptosis]].<br />
<br />
== Clinical Significance ==<br />
Alterations in the expression or function of KDM4A have been implicated in the development and progression of several types of [[Cancer|cancers]]. Overexpression of KDM4A has been observed in prostate, breast, colorectal, and other cancers, where it is thought to promote oncogenesis by activating oncogenes or repressing tumor suppressor genes through its demethylase activity.<br />
<br />
In addition to its role in cancer, KDM4A has been studied for its potential involvement in other diseases, such as neurological disorders, though research in this area is still emerging.<br />
<br />
== Research and Therapeutic Potential ==<br />
Given its role in cancer and other diseases, KDM4A represents a potential target for therapeutic intervention. Inhibitors of KDM4A are being explored for their ability to restore normal histone methylation patterns, thereby reactivating tumor suppressor genes or repressing oncogenes. Early-stage research and preclinical trials are investigating the efficacy of these inhibitors, with the hope of developing new treatments for cancer and possibly other diseases associated with dysregulation of histone methylation.<br />
<br />
== See Also ==<br />
* [[Histone demethylase]]<br />
* [[Epigenetics]]<br />
* [[Oncogene]]<br />
* [[Tumor suppressor gene]]<br />
<br />
== References ==<br />
<references/><br />
<br />
== External Links ==<br />
* [https://www.ncbi.nlm.nih.gov/gene/9682 NCBI Gene entry for KDM4A]<br />
<br />
[[Category:Epigenetics]]<br />
[[Category:Enzymes]]<br />
[[Category:Human proteins]]<br />
{{Medicine-stub}}</div>Prab