https://wikimd.org/index.php?action=history&feed=atom&title=Janus_kinase_2 Janus kinase 2 - Revision history 2026-04-27T03:29:35Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Janus_kinase_2&diff=6524653&oldid=prev Prab at 12:56, 18 March 2025 2025-03-18T12:56:06Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 12:56, 18 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l27">Line 27:</td> <td colspan="2" class="diff-lineno">Line 27:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">__NOINDEX__</del></div></td><td colspan="2" class="diff-side-added"></td></tr> </table> Prab https://wikimd.org/index.php?title=Janus_kinase_2&diff=6510606&oldid=prev Prab: CSV import 2025-03-17T15:33:13Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:33, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l27">Line 27:</td> <td colspan="2" class="diff-lineno">Line 27:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Janus_kinase_2&diff=5338993&oldid=prev Prab: CSV import 2024-03-02T01:47:25Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Janus kinase 2&#039;&#039;&#039; (&#039;&#039;&#039;JAK2&#039;&#039;&#039;) is a non-receptor [[tyrosine kinase]] that plays a crucial role in signal transduction for a variety of [[cellular processes]] including cell growth, differentiation, and apoptosis. It is a member of the [[Janus kinase family]], named after the two-faced Roman god Janus due to their dual functional domains.<br /> <br /> == Structure ==<br /> JAK2 is composed of seven [[JAK homology]] (JH) domains. The JH1 domain is the kinase domain, responsible for the enzymatic activity of the protein. The JH2 domain is a pseudo-kinase domain, which regulates the activity of the JH1 domain. The remaining JH3-JH7 domains are involved in binding to cytokine receptors.<br /> <br /> == Function ==<br /> JAK2 is activated by a variety of [[cytokines]] and [[growth factors]]. Upon ligand binding to the receptor, JAK2 is activated through trans-phosphorylation. The activated JAK2 then phosphorylates and activates [[Signal transducer and activator of transcription|STAT]] proteins, which translocate to the nucleus and regulate gene expression.<br /> <br /> == Clinical significance ==<br /> Mutations in the JAK2 gene are associated with several diseases, including [[Polycythemia vera]], [[Essential thrombocythemia]], and [[Primary myelofibrosis]]. The most common mutation is the JAK2 V617F mutation, which results in constitutive activation of the kinase. This leads to uncontrolled cell proliferation and is a major driver of myeloproliferative neoplasms.<br /> <br /> == Therapeutic implications ==<br /> Given its role in disease, JAK2 is a target for therapeutic intervention. Several JAK2 inhibitors, such as [[Ruxolitinib]] and [[Fedratinib]], have been developed and approved for the treatment of myeloproliferative neoplasms.<br /> <br /> == See also ==<br /> * [[Janus kinase]]<br /> * [[Signal transducer and activator of transcription]]<br /> * [[Myeloproliferative neoplasm]]<br /> <br /> == References ==<br /> &lt;references /&gt;<br /> <br /> [[Category:Protein kinases]]<br /> [[Category:Signal transduction]]<br /> [[Category:Genes]]<br /> {{Protein-stub}}<br /> {{Medicine-stub}}</div> Prab