https://wikimd.org/index.php?action=history&feed=atom&title=Janus_kinase_1 Janus kinase 1 - Revision history 2026-04-28T05:31:35Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Janus_kinase_1&diff=6510643&oldid=prev Prab: CSV import 2025-03-17T15:34:42Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 15:34, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l34">Line 34:</td> <td colspan="2" class="diff-lineno">Line 34:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Enzyme-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Enzyme-stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Janus_kinase_1&diff=6270190&oldid=prev Prab: CSV import 2025-02-11T02:20:57Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 02:20, 11 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l33">Line 33:</td> <td colspan="2" class="diff-lineno">Line 33:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Enzyme-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Enzyme-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Janus_kinase_1&diff=5897734&oldid=prev Prab: CSV import 2024-06-12T19:17:30Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Janus kinase 1&#039;&#039;&#039; (&#039;&#039;&#039;JAK1&#039;&#039;&#039;) is a member of the [[Janus kinase]] family of [[non-receptor tyrosine kinase]]s. JAK1 plays a crucial role in the signaling pathways of various [[cytokine]]s and [[growth factor]]s, which are essential for the regulation of [[immune system|immune]] responses, [[hematopoiesis]], and [[cell growth]].<br /> <br /> ==Structure==<br /> JAK1 is composed of several functional domains, including a [[Ferm domain]], an SH2 domain, and a kinase domain. The kinase domain is responsible for the enzyme&#039;s catalytic activity, while the other domains are involved in protein-protein interactions and the regulation of kinase activity.<br /> <br /> ==Function==<br /> JAK1 is involved in the signaling pathways of multiple cytokines, including [[interferon]]s, [[interleukin]]s, and [[growth hormone]]s. Upon cytokine binding to its receptor, JAK1 is activated through phosphorylation. Activated JAK1 then phosphorylates [[signal transducer and activator of transcription]] (STAT) proteins, which translocate to the [[cell nucleus]] to modulate the expression of target genes.<br /> <br /> ==Clinical Significance==<br /> Mutations in the JAK1 gene have been associated with various [[hematologic malignancies]] and [[immune disorders]]. Inhibitors targeting JAK1 are being developed and tested for the treatment of conditions such as [[rheumatoid arthritis]], [[psoriasis]], and certain types of [[cancer]].<br /> <br /> ==Related Kinases==<br /> JAK1 is closely related to other members of the Janus kinase family, including [[Janus kinase 2|JAK2]], [[Janus kinase 3|JAK3]], and [[Tyrosine-protein kinase JAK|TYK2]]. These kinases share similar structures and functions but are involved in different signaling pathways and physiological processes.<br /> <br /> ==See Also==<br /> * [[Janus kinase]]<br /> * [[Signal transducer and activator of transcription]]<br /> * [[Cytokine receptor]]<br /> * [[Non-receptor tyrosine kinase]]<br /> * [[Hematopoiesis]]<br /> * [[Immune system]]<br /> <br /> ==References==<br /> {{Reflist}}<br /> <br /> ==External Links==<br /> {{Commons category|Janus kinase 1}}<br /> <br /> [[Category:Tyrosine kinases]]<br /> [[Category:Signal transduction]]<br /> [[Category:Immune system]]<br /> [[Category:Hematology]]<br /> <br /> {{Enzyme-stub}}</div> Prab