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	[[Category:Antidiabetic drugs]]		[[Category:Antidiabetic drugs]]
	[[Category:SGLT2 inhibitors]]		[[Category:SGLT2 inhibitors]]
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			File:Janagliflozin.svg\|Janagliflozin
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	~~'''~~Janagliflozin~~''' is a medication used for the treatment of [[Type 2 diabetes]]~~. ~~It belongs to the class of drugs known as [[Sodium-glucose cotransporter 2 inhibitors~~\|~~SGLT2 inhibitors]], which work by preventing the kidneys from reabsorbing glucose back into the blood, thereby promoting the excretion~~ of ~~glucose through urine.~~		{{Short description\|An article about the antidiabetic medication Janagliflozin}}
			{{Drugbox
			\| verifiedrevid = 123456789
			\| image = Janagliflozin.svg
			\| image_size = 200px
			\| image_alt = Structural formula of Janagliflozin
			}}

	~~== Mechanism~~ of ~~Action ==~~		'''Janagliflozin''' is an oral antidiabetic medication used in the management of [[type 2 diabetes mellitus]]. It belongs to the class of drugs known as [[sodium-glucose co-transporter 2 inhibitors]] (SGLT2 inhibitors), which work by preventing the reabsorption of glucose in the kidneys, thereby promoting its excretion in the urine.
	~~Janagliflozin works by inhibiting~~ the [[~~Sodium~~-glucose ~~cotransporter~~ 2~~\|SGLT2~~]] ~~protein in the kidneys. This protein is responsible for approximately 90% of~~ the reabsorption of glucose ~~from~~ the ~~glomerular filtrate back into the blood. By inhibiting this protein~~, ~~Janagliflozin causes an increase in the~~ excretion ~~of glucose~~ in the urine~~, thereby reducing blood glucose levels~~.

	== ~~Uses~~ ==		==Mechanism of Action==
	Janagliflozin ~~is used~~ in the ~~management~~ of [[~~Type 2 diabetes~~]]. ~~It is used as an adjunct~~ to ~~diet~~ and ~~exercise to improve glycemic control~~ in ~~adults with type 2 diabetes mellitus~~.		Janagliflozin functions by inhibiting the [[sodium-glucose co-transporter 2]] (SGLT2) in the proximal tubules of the [[kidney]]. This inhibition reduces the reabsorption of filtered glucose and lowers the renal threshold for glucose, leading to increased urinary glucose excretion and a reduction in blood glucose levels.

	== ~~Side Effects~~ ==		==Pharmacokinetics==
	~~Common side effects of~~ Janagliflozin ~~include urinary~~ tract ~~infections, increased urination,~~ and ~~yeast infections~~ in ~~women. Serious side effects may include~~ [[~~Ketoacidosis~~]], ~~kidney problems,~~ and ~~low blood sugar~~.		Janagliflozin is administered orally and is rapidly absorbed from the gastrointestinal tract. It has a bioavailability of approximately 78% and reaches peak plasma concentrations within 1 to 2 hours after ingestion. The drug is extensively metabolized in the liver, primarily via the [[cytochrome P450]] enzyme system, and is excreted in both urine and feces.

	== ~~Contraindications~~ ==		==Clinical Use==
	Janagliflozin is ~~contraindicated~~ in ~~patients~~ with ~~severe renal impairment~~, ~~end-stage renal disease~~, or ~~dialysis~~. It is ~~also contraindicated~~ in patients with ~~a history~~ of ~~hypersensitivity reaction to Janagliflozin~~.		Janagliflozin is indicated for the treatment of [[type 2 diabetes mellitus]] in adults. It is often used in combination with other antidiabetic agents such as [[metformin]], [[sulfonylureas]], or [[insulin]] to achieve better glycemic control. The medication is not recommended for use in patients with [[type 1 diabetes mellitus]] or for the treatment of [[diabetic ketoacidosis]].

	== ~~Interactions~~ ==		==Side Effects==
	Janagliflozin ~~may interact with other medications such as diuretics~~, ~~insulin~~, and ~~sulfonylureas~~. ~~It is important~~ to ~~inform your healthcare provider about all~~ the ~~medications you are currently taking~~.		Common side effects of Janagliflozin include [[urinary tract infections]], [[genital mycotic infections]], and increased urination. More serious side effects can include [[ketoacidosis]], [[acute kidney injury]], and [[hypotension]]. Patients are advised to maintain adequate hydration to minimize the risk of dehydration and hypotension.

	== ~~See Also~~ ==		==Contraindications==
	* [[~~Sodium-glucose cotransporter 2 inhibitors~~]]		Janagliflozin is contraindicated in patients with severe renal impairment, end-stage renal disease, or those on dialysis. It should also be used with caution in patients with a history of [[hypotension]] or [[electrolyte imbalance]].
	* [[~~Type 2 diabetes~~]]

	[[~~Category:Drugs~~]]		==Related pages==
	[[~~Category:Diabetes~~]]		* [[Type 2 diabetes mellitus]]
			* [[Sodium-glucose co-transporter 2 inhibitors]]
			* [[Metformin]]
			* [[Insulin]]

	~~{{stub}}~~		[[Category:Antidiabetic drugs]]
			[[Category:SGLT2 inhibitors]]

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New page

'''Janagliflozin''' is a medication used for the treatment of [[Type 2 diabetes]]. It belongs to the class of drugs known as [[Sodium-glucose cotransporter 2 inhibitors|SGLT2 inhibitors]], which work by preventing the kidneys from reabsorbing glucose back into the blood, thereby promoting the excretion of glucose through urine.

== Mechanism of Action ==
Janagliflozin works by inhibiting the [[Sodium-glucose cotransporter 2|SGLT2]] protein in the kidneys. This protein is responsible for approximately 90% of the reabsorption of glucose from the glomerular filtrate back into the blood. By inhibiting this protein, Janagliflozin causes an increase in the excretion of glucose in the urine, thereby reducing blood glucose levels.

== Uses ==
Janagliflozin is used in the management of [[Type 2 diabetes]]. It is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

== Side Effects ==
Common side effects of Janagliflozin include urinary tract infections, increased urination, and yeast infections in women. Serious side effects may include [[Ketoacidosis]], kidney problems, and low blood sugar.

== Contraindications ==
Janagliflozin is contraindicated in patients with severe renal impairment, end-stage renal disease, or dialysis. It is also contraindicated in patients with a history of hypersensitivity reaction to Janagliflozin.

== Interactions ==
Janagliflozin may interact with other medications such as diuretics, insulin, and sulfonylureas. It is important to inform your healthcare provider about all the medications you are currently taking.

== See Also ==
* [[Sodium-glucose cotransporter 2 inhibitors]]
* [[Type 2 diabetes]]

[[Category:Drugs]]
[[Category:Diabetes]]

{{stub}}

Janagliflozin - Revision history

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