Prab: CSV import

2025-02-13T03:54:57Z

CSV import

← Older revision		Revision as of 03:54, 13 February 2025
Line 1:		Line 1:
	~~'''~~JWH-249''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a full agonist at both the CB<sub>1</sub> and CB<sub>2</sub> cannabinoid receptors, but with moderate selectivity for CB<sub>1</sub>. It was discovered by and named after Dr. John W. Huffman.		{{DISPLAYTITLE:JWH-249}}

	==~~Chemistry~~==		== Overview ==
	JWH-249 is part of the naphthoylindole family of ~~synthetic cannabinoids~~. ~~It is structurally related to other synthetic cannabinoids including [[~~JWH-~~018]],~~ [[~~JWH-073]], and [[JWH-200~~]]~~. JWH-249 is a full agonist at both the CB<sub>1</sub>~~ and ~~CB<sub>2</sub> cannabinoid receptors, with a moderate selectivity for CB<sub>1</sub>~~.		'''JWH-249''' is a synthetic cannabinoid that acts as a potent agonist of the [[cannabinoid receptor]]s. It is part of the naphthoylindole family of compounds, which are known for their psychoactive effects. JWH-249 was developed in the context of research into the [[endocannabinoid system]] and its potential therapeutic applications.

	==~~Pharmacology~~==		== Chemical Structure ==
	~~As a full agonist at the CB<sub>1</sub> and CB<sub>2</sub> receptors,~~ JWH-249 ~~can produce a wide range~~ of ~~effects similar to those of [[cannabis (drug)\|cannabis~~]]. ~~These effects can include relaxation, euphoria, and altered perception~~. ~~However~~, ~~due to its synthetic nature~~ and ~~the lack~~ of ~~knowledge about its long-term effects, use of JWH-249 can also potentially lead to adverse effects~~.		[[File:JWH-249.svg\|thumb\|right\|Chemical structure of JWH-249]]
			JWH-249 is chemically classified as a naphthoylindole. Its structure consists of a naphthalene ring system attached to an indole moiety. The specific chemical formula for JWH-249 is C23H21NO, and it has a molecular weight of 327.42 g/mol.

	==~~Legal Status~~==		== Pharmacology ==
	~~The legal status of~~ JWH-249 ~~varies by country and region. In some places, it is classified~~ as a ~~controlled substance due to its potential for abuse~~ and the ~~lack~~ of ~~knowledge about its long-term effects~~.		JWH-249 functions primarily as a full agonist at the [[CB1 receptor\|CB1]] and [[CB2 receptor\|CB2]] cannabinoid receptors. These receptors are part of the [[G protein-coupled receptor]] family and are involved in a variety of physiological processes, including modulation of neurotransmitter release, immune response, and [[pain]] perception.

	==~~See Also~~==		=== Mechanism of Action ===
			The mechanism of action of JWH-249 involves binding to the CB1 and CB2 receptors, which are predominantly found in the [[central nervous system]] and [[immune system]], respectively. Upon binding, JWH-249 activates these receptors, leading to a cascade of intracellular events that result in its psychoactive and physiological effects.

			== Effects and Uses ==
			JWH-249, like other synthetic cannabinoids, can produce effects similar to those of [[tetrahydrocannabinol]] (THC), the active component of [[cannabis]]. These effects may include altered perception, mood changes, and euphoria. However, due to its synthetic nature, JWH-249 can also lead to unpredictable and potentially harmful side effects.

			=== Potential Therapeutic Applications ===
			Research into JWH-249 and similar compounds is ongoing, with potential therapeutic applications being explored in areas such as [[pain management]], [[neurological disorders]], and [[inflammation]]. However, the safety and efficacy of JWH-249 for these uses have not been fully established.

			== Legal Status ==
			The legal status of JWH-249 varies by country. In many jurisdictions, it is classified as a controlled substance due to its potential for abuse and lack of accepted medical use. Regulatory agencies continue to monitor and update the legal status of synthetic cannabinoids as new information becomes available.

			== Related Pages ==
	* [[Synthetic cannabinoids]]		* [[Synthetic cannabinoids]]
	* [[Cannabinoid receptor]]		* [[Cannabinoid receptor]]
			* [[Endocannabinoid system]]
	* [[JWH-018]]		* [[JWH-018]]
	* [[JWH-073]]
	* [[JWH-200]]

	~~==References==~~
	~~<references />~~

	[[Category:Synthetic cannabinoids]]		[[Category:Synthetic cannabinoids]]
	[[Category:~~Naphthoylindoles~~]]		[[Category:Research chemicals]]
	~~[[Category:Designer drugs]]~~

	~~{{stub}}~~

Prab: CSV import

2024-02-25T22:58:11Z

CSV import

New page

'''JWH-249''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, but with moderate selectivity for CB1. It was discovered by and named after Dr. John W. Huffman.

==Chemistry==
JWH-249 is part of the naphthoylindole family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids including [[JWH-018]], [[JWH-073]], and [[JWH-200]]. JWH-249 is a full agonist at both the CB1 and CB2 cannabinoid receptors, with a moderate selectivity for CB1.

==Pharmacology==
As a full agonist at the CB1 and CB2 receptors, JWH-249 can produce a wide range of effects similar to those of [[cannabis (drug)|cannabis]]. These effects can include relaxation, euphoria, and altered perception. However, due to its synthetic nature and the lack of knowledge about its long-term effects, use of JWH-249 can also potentially lead to adverse effects.

==Legal Status==
The legal status of JWH-249 varies by country and region. In some places, it is classified as a controlled substance due to its potential for abuse and the lack of knowledge about its long-term effects.

==See Also==
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[JWH-018]]
* [[JWH-073]]
* [[JWH-200]]

==References==
<references />

[[Category:Synthetic cannabinoids]]
[[Category:Naphthoylindoles]]
[[Category:Designer drugs]]

{{stub}}

JWH-249 - Revision history

Prab: CSV import

Prab: CSV import