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	~~'''~~JWH-120''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, but with moderate selectivity for CB2. It was discovered by and named after [[John W. Huffman]], an organic chemist at Clemson University.		{{DISPLAYTITLE:JWH-120}}

	==~~Chemistry~~==		== Overview ==
	JWH-120 is part of the [[naphthoylindole]] family of ~~synthetic cannabinoids. It is structurally related~~ to ~~other synthetic cannabinoids such as~~ [[~~JWH-018~~]] ~~and~~ [[~~JWH-073~~]]~~. The compound is made by substituting an alkyl group at the nitrogen atom of the indole core, and a naphthoyl group at the carbonyl group of the indole~~.		'''JWH-120''' is a synthetic [[cannabinoid]] that acts as a potent agonist at the [[cannabinoid receptor]]s. It is part of the [[naphthoylindole]] family of compounds, which are known for their ability to mimic the effects of [[tetrahydrocannabinol]] (THC), the primary psychoactive component of [[cannabis]].

	==~~Pharmacology~~==		== Chemical Structure ==
	JWH-120 ~~acts as~~ a ~~full agonist at the CB1 and CB2~~ cannabinoid receptors, ~~with a moderate selectivity for CB2. The CB1 and CB2 receptors are part of the~~ [[~~endocannabinoid system~~]]~~, which plays a role in a variety of physiological processes including pain sensation, mood,~~ and ~~memory. The effects of JWH-120 on the human body are similar to those of~~ [[~~cannabis~~]]~~, but it is much more potent than traditional cannabis~~.		[[File:JWH-120.png\|thumb\|right\|Chemical structure of JWH-120]]
			JWH-120 is characterized by its naphthoylindole structure, which includes a naphthalene ring linked to an indole moiety. This structure is crucial for its binding affinity to cannabinoid receptors, particularly [[CB1 receptor\|CB1]] and [[CB2 receptor\|CB2]] receptors.

	==~~Legal Status~~==		== Pharmacology ==
	~~The legal status of~~ JWH-120 ~~varies by country. In the United States, JWH-120 is~~ a ~~Schedule I controlled substance~~, ~~which means it has~~ a ~~high potential~~ for ~~abuse~~ and ~~no accepted medical use. In other countries~~, ~~such~~ as ~~the United Kingdom~~ and ~~Germany, JWH-120 is also controlled under their respective drug laws~~.		JWH-120 functions as a full agonist at both CB1 and CB2 receptors, with a higher affinity for the CB2 receptor. This selectivity makes it of interest in research focused on the [[immune system]] and [[inflammation]], as CB2 receptors are primarily located in peripheral tissues and immune cells.

	==~~Health Risks~~==		=== Mechanism of Action ===
	~~As with other synthetic cannabinoids~~, ~~the use of~~ JWH-120 ~~can lead~~ to ~~serious health risks~~. ~~These include acute kidney injury~~, ~~acute psychosis, and seizures. Long-term use can lead to addiction~~ and ~~withdrawal symptoms~~.		Upon binding to cannabinoid receptors, JWH-120 activates the [[G-protein coupled receptor]] pathways, leading to the inhibition of [[adenylate cyclase]] and a decrease in [[cyclic AMP]] levels. This results in various downstream effects, including modulation of [[neurotransmitter]] release and [[immune response]].

	==~~See Also~~==		== Potential Applications ==
	* [[~~Synthetic cannabinoids~~]]		Research into JWH-120 and similar compounds is ongoing, with potential applications in the treatment of [[pain]], [[inflammation]], and [[neurological disorders]]. However, due to its synthetic nature and potential for abuse, it is also a subject of regulatory scrutiny.

			== Legal Status ==
			The legal status of JWH-120 varies by country. In many jurisdictions, it is classified as a controlled substance due to its psychoactive properties and potential for abuse. Researchers must comply with local regulations when studying this compound.

			== Safety and Toxicity ==
			The safety profile of JWH-120 is not well-established, and its use outside of controlled research settings is not recommended. Potential side effects may include [[tachycardia]], [[anxiety]], and [[hallucinations]], similar to other synthetic cannabinoids.

			== Related Pages ==
	* [[Cannabinoid receptor]]		* [[Cannabinoid receptor]]
	* [[~~John W. Huffman~~]]		* [[Synthetic cannabinoid]]
			* [[JWH series]]
			* [[CB1 receptor]]
			* [[CB2 receptor]]

	[[Category:Synthetic cannabinoids]]		[[Category:Synthetic cannabinoids]]
	[[Category:~~Indoles~~]]		[[Category:Research chemicals]]
	~~[[Category:Naphthoylindoles]]~~
	~~{{pharma-stub}}~~
	~~{{drug-stub}}~~

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2024-02-29T04:24:31Z

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'''JWH-120''' is a synthetic cannabinoid from the naphthoylindole family, which acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, but with moderate selectivity for CB2. It was discovered by and named after [[John W. Huffman]], an organic chemist at Clemson University.

==Chemistry==
JWH-120 is part of the [[naphthoylindole]] family of synthetic cannabinoids. It is structurally related to other synthetic cannabinoids such as [[JWH-018]] and [[JWH-073]]. The compound is made by substituting an alkyl group at the nitrogen atom of the indole core, and a naphthoyl group at the carbonyl group of the indole.

==Pharmacology==
JWH-120 acts as a full agonist at the CB1 and CB2 cannabinoid receptors, with a moderate selectivity for CB2. The CB1 and CB2 receptors are part of the [[endocannabinoid system]], which plays a role in a variety of physiological processes including pain sensation, mood, and memory. The effects of JWH-120 on the human body are similar to those of [[cannabis]], but it is much more potent than traditional cannabis.

==Legal Status==
The legal status of JWH-120 varies by country. In the United States, JWH-120 is a Schedule I controlled substance, which means it has a high potential for abuse and no accepted medical use. In other countries, such as the United Kingdom and Germany, JWH-120 is also controlled under their respective drug laws.

==Health Risks==
As with other synthetic cannabinoids, the use of JWH-120 can lead to serious health risks. These include acute kidney injury, acute psychosis, and seizures. Long-term use can lead to addiction and withdrawal symptoms.

==See Also==
* [[Synthetic cannabinoids]]
* [[Cannabinoid receptor]]
* [[John W. Huffman]]

[[Category:Synthetic cannabinoids]]
[[Category:Indoles]]
[[Category:Naphthoylindoles]]
{{pharma-stub}}
{{drug-stub}}

JWH-120 - Revision history

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