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			== JADE1 ==
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'''JADE1''' (also known as '''Jade Family PHD Finger 1''') is a [[protein]] that in humans is encoded by the '''JADE1''' [[gene]]. It is a [[tumor suppressor]] gene that plays a crucial role in the regulation of [[cell cycle]] and [[apoptosis]].

== Function ==

The '''JADE1''' protein is a part of the HBO1 complex, which is responsible for the [[acetylation]] of [[histone]]s. This process is essential for the regulation of [[transcription (genetics)|transcription]] and is crucial for cell cycle progression and [[DNA damage]] repair. The '''JADE1''' protein also interacts with the [[BRCA1]] tumor suppressor gene and is involved in [[BRCA1]]-mediated [[DNA repair]].

== Clinical Significance ==

Mutations in the '''JADE1''' gene have been associated with various types of [[cancer]], including [[breast cancer]], [[ovarian cancer]], and [[prostate cancer]]. The loss of '''JADE1''' expression is often observed in cancer cells, suggesting that it may play a role in tumor suppression.

== Research ==

Research on '''JADE1''' is ongoing, with studies focusing on its role in cancer development and progression, as well as its potential as a therapeutic target for cancer treatment.

== See Also ==

* [[BRCA1]]
* [[Tumor suppressor gene]]
* [[Histone acetylation and deacetylation]]

== References ==

<references />

[[Category:Genes]]
[[Category:Proteins]]
[[Category:Tumor suppressor genes]]
[[Category:DNA repair]]
[[Category:Cell cycle]]
[[Category:Apoptosis]]
[[Category:Oncology]]
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JADE1 - Revision history

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