Invasive lobular carcinoma - Revision history

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			{{SI}}
			{{Infobox medical condition
			\| name = Invasive lobular carcinoma
			\| image = [[File:Lobules_and_ducts_of_the_breast.jpg\|250px]]
			\| caption = Diagram showing lobules and ducts of the breast
			\| field = [[Oncology]]
			\| synonyms = ILC
			\| symptoms = [[Breast lump]], [[breast pain]], [[nipple discharge]], [[skin changes]]
			\| complications = [[Metastasis]], [[lymphedema]]
			\| onset = Typically in women over 50
			\| duration = Chronic
			\| types = Classic, pleomorphic, alveolar, solid, tubulolobular
			\| causes = [[Genetic mutations]], [[hormonal factors]]
			\| risks = [[Family history]], [[hormone replacement therapy]], [[obesity]]
			\| diagnosis = [[Mammography]], [[ultrasound]], [[biopsy]]
			\| differential = [[Ductal carcinoma in situ]], [[fibroadenoma]], [[mastitis]]
			\| prevention = [[Regular screening]], [[lifestyle changes]]
			\| treatment = [[Surgery]], [[radiation therapy]], [[chemotherapy]], [[hormonal therapy]]
			\| prognosis = Generally good with early detection
			\| frequency = 10-15% of all breast cancers
			\| deaths = Varies depending on stage and treatment
			}}
	{{Short description\|A type of breast cancer that begins in the lobules of the breast}}		{{Short description\|A type of breast cancer that begins in the lobules of the breast}}
	~~{{Medical resources}}~~		[[File:Pie chart of incidence and prognosis of histopathologic breast cancer types.png\|thumb\|Pie chart of incidence and prognosis of histopathologic breast cancer types]]
			[[File:Classic Invasive Lobular Carcinoma of the Breast (6813147194).jpg\|left\|thumb\|Classic Invasive Lobular Carcinoma of the Breast]]
			[[File:Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells.jpg\|thumb\|Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells]]
			[[File:Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ, annotated.jpg\|left\|thumb\|Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ, annotated]]
			[[File:Breast invasive lobular carcinoma (2).jpg\|left\|thumb\|Breast invasive lobular carcinoma]]
			[[File:LobularBreastCancer.jpg\|left\|thumb\|Lobular Breast Cancer]]
			[[File:Histopathology of subtle invasive lobular carcinoma, annotated.png\|thumb\|Histopathology of subtle invasive lobular carcinoma, annotated]]
	'''Invasive lobular carcinoma''' (ILC) is a type of [[breast cancer]] that begins in the [[lobules]] of the breast, which are the glands that produce milk. It is the second most common type of breast cancer after [[invasive ductal carcinoma]].		'''Invasive lobular carcinoma''' (ILC) is a type of [[breast cancer]] that begins in the [[lobules]] of the breast, which are the glands that produce milk. It is the second most common type of breast cancer after [[invasive ductal carcinoma]].

	==Pathophysiology==		==Pathophysiology==
	Invasive lobular carcinoma originates in the lobules, which are the milk-producing glands of the breast. Unlike [[ductal carcinoma]], which begins in the milk ducts, ILC tends to spread in a more diffuse pattern, often making it more challenging to detect on [[mammography]]. The cancer cells invade the surrounding breast tissue and can metastasize to other parts of the body.		Invasive lobular carcinoma originates in the lobules, which are the milk-producing glands of the breast. Unlike [[ductal carcinoma]], which begins in the milk ducts, ILC tends to spread in a more diffuse pattern, often making it more challenging to detect on [[mammography]]. The cancer cells invade the surrounding breast tissue and can metastasize to other parts of the body.

	==Clinical Presentation==		==Clinical Presentation==
	Patients with invasive lobular carcinoma may present with a variety of symptoms. Commonly, there is a thickening or hardening of the breast tissue rather than a distinct lump. Other symptoms can include changes in breast size or shape, skin dimpling, or nipple inversion. Due to its diffuse growth pattern, ILC may not form a palpable mass, making clinical detection more difficult.		Patients with invasive lobular carcinoma may present with a variety of symptoms. Commonly, there is a thickening or hardening of the breast tissue rather than a distinct lump. Other symptoms can include changes in breast size or shape, skin dimpling, or nipple inversion. Due to its diffuse growth pattern, ILC may not form a palpable mass, making clinical detection more difficult.

	==Diagnosis==		==Diagnosis==
	The diagnosis of invasive lobular carcinoma typically involves a combination of imaging studies and biopsy. [[Mammography]] and [[ultrasound]] are commonly used, but due to the diffuse nature of ILC, [[magnetic resonance imaging]] (MRI) may be more effective in some cases. A definitive diagnosis is made through a [[biopsy]], where a sample of breast tissue is examined under a microscope to identify cancerous cells.		The diagnosis of invasive lobular carcinoma typically involves a combination of imaging studies and biopsy. [[Mammography]] and [[ultrasound]] are commonly used, but due to the diffuse nature of ILC, [[magnetic resonance imaging]] (MRI) may be more effective in some cases. A definitive diagnosis is made through a [[biopsy]], where a sample of breast tissue is examined under a microscope to identify cancerous cells.

	==Histological Features==		==Histological Features==
	Under the microscope, invasive lobular carcinoma is characterized by small, non-cohesive cells that invade the stroma in a single-file pattern. This is due to the loss of [[E-cadherin]], a protein that helps cells stick together. The lack of E-cadherin is a hallmark of ILC and helps differentiate it from other types of breast cancer.		Under the microscope, invasive lobular carcinoma is characterized by small, non-cohesive cells that invade the stroma in a single-file pattern. This is due to the loss of [[E-cadherin]], a protein that helps cells stick together. The lack of E-cadherin is a hallmark of ILC and helps differentiate it from other types of breast cancer.

	==Treatment==		==Treatment==
	The treatment of invasive lobular carcinoma typically involves a combination of surgery, radiation therapy, and systemic therapies such as [[chemotherapy]], [[hormone therapy]], and [[targeted therapy]]. The choice of treatment depends on the stage of the cancer, hormone receptor status, and other factors.		The treatment of invasive lobular carcinoma typically involves a combination of surgery, radiation therapy, and systemic therapies such as [[chemotherapy]], [[hormone therapy]], and [[targeted therapy]]. The choice of treatment depends on the stage of the cancer, hormone receptor status, and other factors.

	===Surgical Options===		===Surgical Options===
	Surgical treatment may include [[lumpectomy]] or [[mastectomy]], depending on the size and location of the tumor and patient preference. Sentinel lymph node biopsy or axillary lymph node dissection may be performed to assess the spread of cancer to the lymph nodes.		Surgical treatment may include [[lumpectomy]] or [[mastectomy]], depending on the size and location of the tumor and patient preference. Sentinel lymph node biopsy or axillary lymph node dissection may be performed to assess the spread of cancer to the lymph nodes.

	===Systemic Therapies===		===Systemic Therapies===
	Hormone therapy is often used in cases where the cancer is hormone receptor-positive. Common medications include [[tamoxifen]] and [[aromatase inhibitors]]. Chemotherapy may be recommended for more advanced stages or aggressive forms of ILC. Targeted therapies, such as [[HER2 inhibitors]], are used if the cancer overexpresses the HER2 protein.		Hormone therapy is often used in cases where the cancer is hormone receptor-positive. Common medications include [[tamoxifen]] and [[aromatase inhibitors]]. Chemotherapy may be recommended for more advanced stages or aggressive forms of ILC. Targeted therapies, such as [[HER2 inhibitors]], are used if the cancer overexpresses the HER2 protein.

	==Prognosis==		==Prognosis==
	The prognosis for patients with invasive lobular carcinoma varies depending on the stage at diagnosis and other factors such as hormone receptor status. Generally, ILC has a similar prognosis to invasive ductal carcinoma when matched for stage and other prognostic factors. However, due to its tendency to be diagnosed at a later stage, careful monitoring and follow-up are essential.		The prognosis for patients with invasive lobular carcinoma varies depending on the stage at diagnosis and other factors such as hormone receptor status. Generally, ILC has a similar prognosis to invasive ductal carcinoma when matched for stage and other prognostic factors. However, due to its tendency to be diagnosed at a later stage, careful monitoring and follow-up are essential.
			==See also==
	==~~Related pages~~==
	* [[Breast cancer]]		* [[Breast cancer]]
	* [[Invasive ductal carcinoma]]		* [[Invasive ductal carcinoma]]
	* [[Mammography]]		* [[Mammography]]
	* [[Hormone therapy (oncology)]]		* [[Hormone therapy (oncology)]]
			[[Category:Breast cancer]]]]
	[[Category:Breast cancer]]
	~~<gallery>~~
	~~File:Lobules and ducts of the breast.jpg\|Lobules and ducts of the breast~~
	~~File:Pie chart of incidence and prognosis of histopathologic breast cancer types.png\|Pie chart of incidence and prognosis of histopathologic breast cancer types~~
	~~File:Classic Invasive Lobular Carcinoma of the Breast (6813147194).jpg\|Classic Invasive Lobular Carcinoma of the Breast~~
	~~File:Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells.jpg\|Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells~~
	~~File:Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ, annotated.jpg\|Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ, annotated~~
	~~File:Breast invasive lobular carcinoma (2).jpg\|Breast invasive lobular carcinoma~~
	~~File:LobularBreastCancer.jpg\|Lobular Breast Cancer~~
	~~File:Histopathology of subtle invasive lobular carcinoma, annotated.png\|Histopathology of subtle invasive lobular carcinoma, annotated~~
	~~</gallery>~~

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	[[Category:Breast cancer]]		[[Category:Breast cancer]]
			<gallery>
			File:Lobules and ducts of the breast.jpg\|Lobules and ducts of the breast
			File:Pie chart of incidence and prognosis of histopathologic breast cancer types.png\|Pie chart of incidence and prognosis of histopathologic breast cancer types
			File:Classic Invasive Lobular Carcinoma of the Breast (6813147194).jpg\|Classic Invasive Lobular Carcinoma of the Breast
			File:Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells.jpg\|Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells
			File:Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ, annotated.jpg\|Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ, annotated
			File:Breast invasive lobular carcinoma (2).jpg\|Breast invasive lobular carcinoma
			File:LobularBreastCancer.jpg\|Lobular Breast Cancer
			File:Histopathology of subtle invasive lobular carcinoma, annotated.png\|Histopathology of subtle invasive lobular carcinoma, annotated
			</gallery>

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2025-02-18T17:31:32Z

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← Older revision		Revision as of 17:31, 18 February 2025
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	~~'''Invasive lobular carcinoma''' ('''ILC''') is the second most common~~ type of ~~[[Breast cancer\|~~breast cancer~~]] after [[Invasive ductal carcinoma\|invasive ductal carcinoma]] (IDC). It is characterized by cancer cells~~ that ~~have spread from~~ the ~~[[Lobules~~ of the ~~mammary gland\|lobules]] where they originated into the surrounding~~ breast ~~tissue.~~		{{Short description\|A type of breast cancer that begins in the lobules of the breast}}
			{{Medical resources}}

	~~==Epidemiology==~~		'''Invasive lobular carcinoma''' (ILC) is a type of [[breast cancer]] that begins in the [[lobules]] of the breast, which are the glands that produce milk. It is the second most common type of breast cancer after [[invasive ductal carcinoma]].
	ILC ~~accounts for approximately 10%~~ of ~~all~~ breast ~~cancers~~. It is ~~more~~ common ~~in older women, with the majority~~ of ~~cases occurring in women over the age of 55~~.

	==Pathophysiology==		==Pathophysiology==
	~~In ILC~~, ~~cancer cells originate in~~ the milk-producing ~~lobules and then invade~~ the ~~surrounding~~ breast ~~tissue~~. ~~These cells can also spread to other parts of the body through the~~ [[~~Lymphatic system\|lymphatic system~~]] ~~and~~ the ~~bloodstream. Unlike IDC~~, ILC tends to ~~occur in multiple areas~~ in the breast and ~~is often bilateral, affecting both breasts~~.		Invasive lobular carcinoma originates in the lobules, which are the milk-producing glands of the breast. Unlike [[ductal carcinoma]], which begins in the milk ducts, ILC tends to spread in a more diffuse pattern, often making it more challenging to detect on [[mammography]]. The cancer cells invade the surrounding breast tissue and can metastasize to other parts of the body.

	==Clinical Presentation==		==Clinical Presentation==
	~~The symptoms of ILC~~ may ~~be less obvious than those~~ of ~~IDC~~. ~~The most common symptom~~ is a ~~change in the texture~~ of the breast tissue~~, often described as~~ a ~~thickening or fullness in one part of the breast~~. Other symptoms can include ~~a newly inverted nipple~~ or skin ~~changes such as~~ dimpling or ~~puckering~~.		Patients with invasive lobular carcinoma may present with a variety of symptoms. Commonly, there is a thickening or hardening of the breast tissue rather than a distinct lump. Other symptoms can include changes in breast size or shape, skin dimpling, or nipple inversion. Due to its diffuse growth pattern, ILC may not form a palpable mass, making clinical detection more difficult.

	==Diagnosis==		==Diagnosis==
	~~Diagnosis~~ of ~~ILC can be more challenging than other types~~ of ~~breast cancer due to its subtle symptoms~~ and ~~the fact that it often does not form a distinct lump~~. ~~It may not be detected on a~~ [[Mammography~~\|mammogram~~]] and ~~may require additional imaging tests such as an~~ [[~~Ultrasound\|~~ultrasound]] or [[~~Magnetic~~ resonance imaging~~\|MRI~~]]. A definitive diagnosis is made through a [[~~Biopsy\|~~biopsy]] of the ~~suspicious tissue~~.		The diagnosis of invasive lobular carcinoma typically involves a combination of imaging studies and biopsy. [[Mammography]] and [[ultrasound]] are commonly used, but due to the diffuse nature of ILC, [[magnetic resonance imaging]] (MRI) may be more effective in some cases. A definitive diagnosis is made through a [[biopsy]], where a sample of breast tissue is examined under a microscope to identify cancerous cells.

			==Histological Features==
			Under the microscope, invasive lobular carcinoma is characterized by small, non-cohesive cells that invade the stroma in a single-file pattern. This is due to the loss of [[E-cadherin]], a protein that helps cells stick together. The lack of E-cadherin is a hallmark of ILC and helps differentiate it from other types of breast cancer.

	==Treatment==		==Treatment==
	The treatment ~~for ILC is similar to that for other types~~ of ~~breast cancer and may include~~ surgery, ~~[[Radiation therapy\|~~radiation therapy]], [[~~Chemotherapy\|~~chemotherapy]], [[~~Hormone therapy\|~~hormone therapy]], and targeted ~~therapies~~. The choice of treatment depends on the stage of the cancer, the patient~~'s overall health~~, ~~and their personal preferences~~.		The treatment of invasive lobular carcinoma typically involves a combination of surgery, radiation therapy, and systemic therapies such as [[chemotherapy]], [[hormone therapy]], and [[targeted therapy]]. The choice of treatment depends on the stage of the cancer, hormone receptor status, and other factors.

			===Surgical Options===
			Surgical treatment may include [[lumpectomy]] or [[mastectomy]], depending on the size and location of the tumor and patient preference. Sentinel lymph node biopsy or axillary lymph node dissection may be performed to assess the spread of cancer to the lymph nodes.

			===Systemic Therapies===
			Hormone therapy is often used in cases where the cancer is hormone receptor-positive. Common medications include [[tamoxifen]] and [[aromatase inhibitors]]. Chemotherapy may be recommended for more advanced stages or aggressive forms of ILC. Targeted therapies, such as [[HER2 inhibitors]], are used if the cancer overexpresses the HER2 protein.

	==Prognosis==		==Prognosis==
	The prognosis for ILC ~~is generally~~ similar to ~~that~~ for ~~IDC when detected~~ and ~~treated at the same stage~~. However, ~~because ILC is often~~ diagnosed at a later stage ~~due to its subtle symptoms~~, ~~the overall survival rate may be slightly lower~~.		The prognosis for patients with invasive lobular carcinoma varies depending on the stage at diagnosis and other factors such as hormone receptor status. Generally, ILC has a similar prognosis to invasive ductal carcinoma when matched for stage and other prognostic factors. However, due to its tendency to be diagnosed at a later stage, careful monitoring and follow-up are essential.

	==~~See Also~~==		==Related pages==
	* [[Breast cancer]]		* [[Breast cancer]]
	* [[Invasive ductal carcinoma]]		* [[Invasive ductal carcinoma]]
	* [[Lobules of the mammary gland]]
	* [[Lymphatic system]]
	* [[Mammography]]		* [[Mammography]]
	* [[Ultrasound]]		* [[Hormone therapy (oncology)]]
	* [[Magnetic resonance imaging]]
	* [[Biopsy]]
	* [[Radiation therapy]]
	* [[Chemotherapy]]
	* [[Hormone therapy]]

	[[Category:Breast cancer]]		[[Category:Breast cancer]]
	~~[[Category:Carcinoma]]~~
	~~[[Category:Oncology]]~~
	~~{{Breast cancer}}~~
	~~{{Carcinoma}}~~
	~~{{Oncology}}~~
	~~{{medicine-stub}}~~
	~~<gallery>~~
	~~File:Lobules_and_ducts_of_the_breast.jpg\|Lobules and ducts of the breast~~
	~~File:Pie_chart_of_incidence_and_prognosis_of_histopathologic_breast_cancer_types.png\|Pie chart of incidence and prognosis of histopathologic breast cancer types~~
	~~File:Classic_Invasive_Lobular_Carcinoma_of_the_Breast_(6813147194).jpg\|Classic Invasive Lobular Carcinoma of the Breast~~
	~~File:Histopathology_of_pleomorphic_lobular_carcinoma_with_plasmacytoid_cells.jpg\|Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells~~
	~~File:Histopathology_of_invasive_lobular_carcinoma,_next_to_lobular_carcinoma_in_situ,_annotated.jpg\|Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ~~
	~~File:Breast_invasive_lobular_carcinoma_(2).jpg\|Breast invasive lobular carcinoma~~
	~~File:LobularBreastCancer.jpg\|Lobular Breast Cancer~~
	~~File:Histopathology_of_subtle_invasive_lobular_carcinoma,_annotated.png\|Histopathology of subtle invasive lobular carcinoma~~
	~~</gallery>~~

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	{{Oncology}}		{{Oncology}}
	{{medicine-stub}}		{{medicine-stub}}
			<gallery>
			File:Lobules_and_ducts_of_the_breast.jpg\|Lobules and ducts of the breast
			File:Pie_chart_of_incidence_and_prognosis_of_histopathologic_breast_cancer_types.png\|Pie chart of incidence and prognosis of histopathologic breast cancer types
			File:Classic_Invasive_Lobular_Carcinoma_of_the_Breast_(6813147194).jpg\|Classic Invasive Lobular Carcinoma of the Breast
			File:Histopathology_of_pleomorphic_lobular_carcinoma_with_plasmacytoid_cells.jpg\|Histopathology of pleomorphic lobular carcinoma with plasmacytoid cells
			File:Histopathology_of_invasive_lobular_carcinoma,_next_to_lobular_carcinoma_in_situ,_annotated.jpg\|Histopathology of invasive lobular carcinoma, next to lobular carcinoma in situ
			File:Breast_invasive_lobular_carcinoma_(2).jpg\|Breast invasive lobular carcinoma
			File:LobularBreastCancer.jpg\|Lobular Breast Cancer
			File:Histopathology_of_subtle_invasive_lobular_carcinoma,_annotated.png\|Histopathology of subtle invasive lobular carcinoma
			</gallery>

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New page

'''Invasive lobular carcinoma''' ('''ILC''') is the second most common type of [[Breast cancer|breast cancer]] after [[Invasive ductal carcinoma|invasive ductal carcinoma]] (IDC). It is characterized by cancer cells that have spread from the [[Lobules of the mammary gland|lobules]] where they originated into the surrounding breast tissue.

==Epidemiology==
ILC accounts for approximately 10% of all breast cancers. It is more common in older women, with the majority of cases occurring in women over the age of 55.

==Pathophysiology==
In ILC, cancer cells originate in the milk-producing lobules and then invade the surrounding breast tissue. These cells can also spread to other parts of the body through the [[Lymphatic system|lymphatic system]] and the bloodstream. Unlike IDC, ILC tends to occur in multiple areas in the breast and is often bilateral, affecting both breasts.

==Clinical Presentation==
The symptoms of ILC may be less obvious than those of IDC. The most common symptom is a change in the texture of the breast tissue, often described as a thickening or fullness in one part of the breast. Other symptoms can include a newly inverted nipple or skin changes such as dimpling or puckering.

==Diagnosis==
Diagnosis of ILC can be more challenging than other types of breast cancer due to its subtle symptoms and the fact that it often does not form a distinct lump. It may not be detected on a [[Mammography|mammogram]] and may require additional imaging tests such as an [[Ultrasound|ultrasound]] or [[Magnetic resonance imaging|MRI]]. A definitive diagnosis is made through a [[Biopsy|biopsy]] of the suspicious tissue.

==Treatment==
The treatment for ILC is similar to that for other types of breast cancer and may include surgery, [[Radiation therapy|radiation therapy]], [[Chemotherapy|chemotherapy]], [[Hormone therapy|hormone therapy]], and targeted therapies. The choice of treatment depends on the stage of the cancer, the patient's overall health, and their personal preferences.

==Prognosis==
The prognosis for ILC is generally similar to that for IDC when detected and treated at the same stage. However, because ILC is often diagnosed at a later stage due to its subtle symptoms, the overall survival rate may be slightly lower.

==See Also==
* [[Breast cancer]]
* [[Invasive ductal carcinoma]]
* [[Lobules of the mammary gland]]
* [[Lymphatic system]]
* [[Mammography]]
* [[Ultrasound]]
* [[Magnetic resonance imaging]]
* [[Biopsy]]
* [[Radiation therapy]]
* [[Chemotherapy]]
* [[Hormone therapy]]

[[Category:Breast cancer]]
[[Category:Carcinoma]]
[[Category:Oncology]]
{{Breast cancer}}
{{Carcinoma}}
{{Oncology}}
{{medicine-stub}}