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2025-02-13T03:44:48Z

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	~~'''~~Interleukin 24''' (IL-24) is a [[protein]] that in humans is encoded by the IL24 [[gene]]. It is a member of the [[interleukin]] family of [[cytokines]], which are small proteins important in cell signaling. IL-24 is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a gene that is up-regulated during the induction of terminal differentiation in melanoma cells.		{{DISPLAYTITLE:Interleukin 24}}

	== ~~Function~~ ==		== Interleukin 24 ==
	IL-24 is ~~produced by~~ [[~~immune cells~~]] ~~and acts on non-immune cells~~, ~~such as~~ [[~~epithelial cells]] and [[fibroblasts~~]]. It ~~has been shown to inhibit~~ the ~~growth of~~ [[~~tumor~~]] ~~cells~~ and is ~~also involved in the immune response against infections. IL-24 can~~ induce [[apoptosis]] in cancer cells ~~without affecting~~ normal cells.		[[File:CC-BY_icon.svg\|thumb\|right\|Interleukin 24 structure]]
			'''Interleukin 24''' (IL-24) is a cytokine that belongs to the [[interleukin]] family, which plays a crucial role in the [[immune system]]. It is part of the larger [[IL-10]] cytokine family and is known for its ability to induce [[apoptosis]] in various [[cancer]] cells while sparing normal cells.

	== ~~Clinical significance~~ ==		== Structure and Function ==
	IL-24 ~~has been studied for its potential use in~~ [[~~cancer therapy~~]]. It ~~has been shown~~ to selectively ~~kill various types of~~ cancer cells ~~while having little~~ to ~~no effect~~ on ~~normal~~ cells~~. This selective killing is believed~~ to ~~be due to the activation of multiple~~ cell death ~~pathways in cancer cells by IL-24~~.		IL-24 is a protein encoded by the [[IL24 gene]] in humans. It is characterized by its unique ability to selectively target cancer cells, making it a potential therapeutic agent in [[oncology]]. The cytokine functions by binding to specific [[receptors]] on the surface of target cells, initiating a cascade of intracellular signals that lead to cell death.

	== ~~See~~ also ==		== Mechanism of Action ==
			[[File:CC-BY_icon.svg\|thumb\|left\|Mechanism of IL-24 action]]
			The mechanism by which IL-24 induces apoptosis involves the activation of the [[JAK-STAT signaling pathway]], which is crucial for transmitting information from extracellular chemical signals to the cell nucleus, resulting in gene expression changes. IL-24 also interacts with the [[endoplasmic reticulum]] stress pathways, further promoting apoptosis in cancer cells.

			== Clinical Implications ==
			IL-24 has been studied for its potential use in [[gene therapy]] for cancer treatment. Its ability to selectively induce apoptosis in cancer cells without affecting normal cells makes it an attractive candidate for therapeutic development. Clinical trials are ongoing to evaluate the efficacy and safety of IL-24-based therapies in various types of cancer.

			== Related Cytokines ==
			IL-24 is closely related to other cytokines in the IL-10 family, such as [[IL-19]], [[IL-20]], and [[IL-22]]. These cytokines share structural similarities and often have overlapping functions in immune regulation and inflammation.

			== Research and Development ==
			Ongoing research is focused on understanding the detailed molecular mechanisms of IL-24 and its interactions with other cellular pathways. Scientists are also exploring the potential of IL-24 in combination with other cancer therapies to enhance its efficacy and overcome resistance.

			== Related Pages ==
	* [[Interleukin]]		* [[Interleukin]]
	* [[Cytokine]]		* [[Cytokine]]
	* [[Apoptosis]]		* [[Apoptosis]]
	* [[Cancer therapy]]		* [[Cancer therapy]]
			* [[Gene therapy]]
	~~== References ==~~
	~~<references />~~

	~~== External links ==~~
	* [~~https://www.ncbi.nlm.nih.gov/gene/11009 IL24 gene] at~~ [~~[National Center for Biotechnology Information\|NCBI]]~~
	* [https://www.uniprot.org/uniprot/Q13007 IL24 protein] at [[UniProt]]

	[[Category:Interleukins]]		[[Category:Interleukins]]
	[[Category:Cytokines]]		[[Category:Cytokines]]
	[[Category:~~Apoptosis~~]]		[[Category:Immunology]]
	~~[[Category:Cancer therapy]]~~

	~~{{stub}}~~

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2024-02-24T05:32:04Z

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'''Interleukin 24''' (IL-24) is a [[protein]] that in humans is encoded by the IL24 [[gene]]. It is a member of the [[interleukin]] family of [[cytokines]], which are small proteins important in cell signaling. IL-24 is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a gene that is up-regulated during the induction of terminal differentiation in melanoma cells.

== Function ==
IL-24 is produced by [[immune cells]] and acts on non-immune cells, such as [[epithelial cells]] and [[fibroblasts]]. It has been shown to inhibit the growth of [[tumor]] cells and is also involved in the immune response against infections. IL-24 can induce [[apoptosis]] in cancer cells without affecting normal cells.

== Clinical significance ==
IL-24 has been studied for its potential use in [[cancer therapy]]. It has been shown to selectively kill various types of cancer cells while having little to no effect on normal cells. This selective killing is believed to be due to the activation of multiple cell death pathways in cancer cells by IL-24.

== See also ==
* [[Interleukin]]
* [[Cytokine]]
* [[Apoptosis]]
* [[Cancer therapy]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/11009 IL24 gene] at [[National Center for Biotechnology Information|NCBI]]
* [https://www.uniprot.org/uniprot/Q13007 IL24 protein] at [[UniProt]]

[[Category:Interleukins]]
[[Category:Cytokines]]
[[Category:Apoptosis]]
[[Category:Cancer therapy]]

{{stub}}

Interleukin 24 - Revision history

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Prab: CSV import