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	'''Interleukin 23''' (IL-23) is a [[cytokine]] that plays a crucial role in the [[immune system]]. It is ~~produced by [[dendritic cells]]~~ and [[~~macrophages~~]] ~~in response to pathogen entry in the body~~. IL-23 is ~~known to be involved in inflammatory responses~~ and ~~is implicated in several autoimmune diseases~~.		{{DISPLAYTITLE:Interleukin 23}}

			== Interleukin 23 ==
			[[File:IL12b_Crystal_Structure.rsh.png\|thumb\|right\|Crystal structure of IL-12, a cytokine related to IL-23]]
			'''Interleukin 23''' (IL-23) is a [[cytokine]] that plays a crucial role in the [[immune system]]. It is involved in the inflammatory response and is important in the pathogenesis of several [[autoimmune diseases]]. IL-23 is a member of the [[IL-12]] cytokine family and shares a common subunit with IL-12.

	== Structure ==		== Structure ==
	IL-23 is a heterodimeric cytokine composed of two subunits: the p19 ~~subunit and the p40~~ subunit, which ~~is shared with [[Interleukin 12\|IL-12]]. The p19 subunit~~ is unique to IL-23, ~~while~~ the p40 subunit is shared with IL-12. The ~~p19~~ subunit is encoded by the ~~IL23A~~ gene, ~~and~~ the ~~p40 subunit~~ is ~~encoded by~~ the ~~IL12B gene~~.		IL-23 is a heterodimeric cytokine composed of two subunits: the p19 subunit, which is unique to IL-23, and the p40 subunit, which is shared with IL-12. The p40 subunit is encoded by the [[IL12B]] gene. The structure of IL-23 allows it to bind to its specific receptor, the [[IL-23 receptor]], which is expressed on the surface of certain [[immune cells]].

	== Function ==		== Function ==
	IL-23 is ~~involved~~ in the differentiation of ~~naive~~ T-cells ~~into~~ Th17 cells, which ~~produce~~ [[~~Interleukin 17\|IL-17~~]]. IL-23 ~~stimulates~~ the production of ~~other~~ cytokines ~~from T~~-~~cells~~ and ~~macrophages, and increases the expression of the receptor~~ [[~~Interleukin 12 receptor beta 2\|~~IL-~~12Rβ2~~]] ~~on the T-cell surface. IL-23 also promotes the survival~~ and ~~proliferation of T-cells~~.		IL-23 is primarily produced by [[dendritic cells]] and [[macrophages]]. It plays a key role in the differentiation and maintenance of [[T helper 17 cells]] (Th17 cells), which are a subset of [[T cells]] involved in the immune response against extracellular pathogens and in the development of [[autoimmune diseases]]. IL-23 promotes the production of [[pro-inflammatory cytokines]] such as [[IL-17]] and [[IL-22]], which contribute to inflammation and tissue damage in autoimmune conditions.

	== Role in Disease ==		== Role in Disease ==
	IL-23 is implicated in several autoimmune diseases, including [[psoriasis]], [[rheumatoid arthritis]], ~~and~~ [[inflammatory bowel disease]]. ~~It is thought to contribute to~~ the ~~pathogenesis of these diseases~~ by promoting inflammation and ~~the production of pro-inflammatory cytokines. Inhibitors of IL-23 are being investigated as potential treatments for these diseases~~.		IL-23 has been implicated in the pathogenesis of several autoimmune diseases, including [[psoriasis]], [[rheumatoid arthritis]], [[inflammatory bowel disease]], and [[multiple sclerosis]]. In these conditions, IL-23 drives the inflammatory response by promoting the expansion and activation of Th17 cells, leading to chronic inflammation and tissue damage.

	== ~~See Also~~ ==		== Therapeutic Target ==
	* [[~~Interleukin~~]]		Due to its role in autoimmune diseases, IL-23 is a target for therapeutic intervention. Several [[biologic drugs]] have been developed to inhibit IL-23 signaling, including monoclonal antibodies that specifically target the p19 subunit of IL-23. These therapies have shown efficacy in treating conditions such as psoriasis and Crohn's disease by reducing inflammation and improving clinical symptoms.

			== Related pages ==
	* [[Cytokine]]		* [[Cytokine]]
			* [[IL-12]]
			* [[T helper 17 cells]]
	* [[Autoimmune disease]]		* [[Autoimmune disease]]

	~~== References ==~~		[[Category:Interleukins]]
	~~<references />~~

	~~{{Cytokines}}~~
	[[Category:~~Cytokines~~]]
	[[Category:Immunology]]		[[Category:Immunology]]
	~~[[Category:Autoimmune diseases]]~~
	~~{{Immunology-stub}}~~

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'''Interleukin 23''' (IL-23) is a [[cytokine]] that plays a crucial role in the [[immune system]]. It is produced by [[dendritic cells]] and [[macrophages]] in response to pathogen entry in the body. IL-23 is known to be involved in inflammatory responses and is implicated in several autoimmune diseases.

== Structure ==
IL-23 is a heterodimeric cytokine composed of two subunits: the p19 subunit and the p40 subunit, which is shared with [[Interleukin 12|IL-12]]. The p19 subunit is unique to IL-23, while the p40 subunit is shared with IL-12. The p19 subunit is encoded by the IL23A gene, and the p40 subunit is encoded by the IL12B gene.

== Function ==
IL-23 is involved in the differentiation of naive T-cells into Th17 cells, which produce [[Interleukin 17|IL-17]]. IL-23 stimulates the production of other cytokines from T-cells and macrophages, and increases the expression of the receptor [[Interleukin 12 receptor beta 2|IL-12Rβ2]] on the T-cell surface. IL-23 also promotes the survival and proliferation of T-cells.

== Role in Disease ==
IL-23 is implicated in several autoimmune diseases, including [[psoriasis]], [[rheumatoid arthritis]], and [[inflammatory bowel disease]]. It is thought to contribute to the pathogenesis of these diseases by promoting inflammation and the production of pro-inflammatory cytokines. Inhibitors of IL-23 are being investigated as potential treatments for these diseases.

== See Also ==
* [[Interleukin]]
* [[Cytokine]]
* [[Autoimmune disease]]

== References ==
<references />

{{Cytokines}}
[[Category:Cytokines]]
[[Category:Immunology]]
[[Category:Autoimmune diseases]]
{{Immunology-stub}}

Interleukin 23 - Revision history

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