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'''Interleukin 22''' (IL-22) is a protein that in humans is encoded by the IL22 gene. It is a member of a group of molecules known as [[cytokines]], which are important in the immune response. IL-22 is produced by several types of cells, including [[T cells]] and [[natural killer cells]], and has various effects on the cells that it targets.

== Function ==
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-24, IL-26, IL-28, and IL-29. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by [[T lymphocytes]], IL-22 inhibits [[antigen presentation]] by [[dendritic cells]]. Two types of IL-22 binding receptor have been discovered, both of which are members of the class II cytokine receptor (CRF2) family: IL-22Ra1 and IL-22Ra2.

== Clinical significance ==
IL-22 has been shown to be involved in several types of [[autoimmune disease]], including [[psoriasis]], [[rheumatoid arthritis]], and [[inflammatory bowel disease]]. It is also implicated in the immune response to [[tuberculosis]]. IL-22 may be a potential therapeutic target in these diseases.

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/50616 IL22 gene] at NCBI
* [https://www.uniprot.org/uniprot/Q9GZX6 IL22 protein] at UniProt

[[Category:Cytokines]]
[[Category:Interleukins]]
[[Category:Immunology]]
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Interleukin 22 - Revision history

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